Similar studies for GEO DataSets (Select 3350) - GEO DataSets

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Items: 18

Select item 33501.

STAT5 depleted pro-B cell line response to IL-3: time course (MG-U74B)

Analysis of STAT5A and STAT5B depleted pro-B Ba/F3-beta cells stimulated with IL-3 for 0.5 or 2 hours. STAT5A and STAT5B are members of the family of signal transducers and activators of transcription. Results identify IL-3 inducible STAT5 target genes.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent, 2 protocol, 3 time sets

Platform:: GPL82
Series:: GSE10389
5 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS3350

ID:: 3350

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000103892.

Identification of Stat5 Target Genes by siRNA-mediated knockdown

(Submitter supplied) STAT5A and STAT5B proteins belong to the family of signal transducers and activators of transcription. They are encoded by 2 separate genes with 91% identity in their amino acid sequences. Despite their high degree of conservation, STAT5A and STAT5B exert non-redundant functions, resulting at least in part from differences in target gene activation. To better characterize the differential contribution of STAT5A and STAT5B in gene regulation, we performed single or double knock-down of STAT5A and STAT5B using small interfering RNA. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Datasets:: GDS3349 GDS3350 GDS3351
Platforms:: GPL83 GPL81 GPL82
15 Samples

Download data: CEL, CHP

Series

Accession:: GSE10389

ID:: 200010389

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 33513.

STAT5 depleted pro-B cell line response to IL-3: time course (MG-U74C)

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent, 2 protocol, 3 time sets

Platform:: GPL83
Series:: GSE10389
5 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS3351

ID:: 3351

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 33494.

STAT5 depleted pro-B cell line response to IL-3: time course (MG-U74A)

Analysis of STAT5A and STAT5B depleted proB Ba/F3-beta cells stimulated with IL-3 for 0.5 or 2 hours. STAT5A and STAT5B are members of the family of signal transducers and activators of transcription. Results identify IL-3 inducible STAT5 target genes.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent, 2 protocol, 3 time sets

Platform:: GPL81
Series:: GSE10389
5 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS3349

ID:: 3349

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000071705.

Sex-dependent and strain-dependent gene liver gene expression

(Submitter supplied) A series of dual-channel gene expression profiles obtained using Agilent Mouse TOE 75k microarrays was used to examine the sex-dependent differences in gene expression across three outbred mouse strains, 129J x Black Swiss, 129J x BALB/c, and ICR. This series is comprised of samples obtained from 3 pools of randomly chosen independent cDNA samples of male and female 129Jx BALB/c mice and 3 randomly chosen independent cDNA samples of male and female 129J x Black Swiss mice and 5 randomly chosen independent cDNA samples of male and female ICR mice. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL3562
10 Samples

Download data: TXT

Series

Accession:: GSE7170

ID:: 200007170

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000071696.

Sex-dependent and STAT5a-dependent Liver Gene Expression

(Submitter supplied) A series of dual-channel gene expression profiles obtained using Agilent Mouse TOE 75k microarrays was used to examine the sex-dependent and STAT5a-dependent differences in gene expression in adult mouse liver. This series is comprised of 3 randomly chosen independent male and female wildtype mouse liver cDNA samples and 3 randomly chosen independent male and female STAT5a-deficient mouse liver cDNA samples, totalling 12 samples. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL3562
12 Samples

Download data: TXT

Series

Accession:: GSE7169

ID:: 200007169

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000795207.

The dual role of LSD1 and HDAC3 in STAT5-dependent transcription is determined by protein interactions, binding affinities, motifs and genomic positions.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL13112 GPL19057
40 Samples

Download data: BED, BEDGRAPH, TXT

Series

Accession:: GSE79520

ID:: 200079520

PubMed Full text in PMC Similar studies

Select item 2000795198.

The dual role of LSD1 and HDAC3 in STAT5-dependent transcription is determined by protein interactions, binding affinities, motifs and genomic positions [RNA-seq]

(Submitter supplied) STAT5 interacts with other factors to control transcription, and the mechanism of regulation is of interest as constitutive active STAT5 has been reported in malignancies. Here LSD1 and HDAC3 were identified as novel STAT5a interacting partners in pro-B cells. Characterization of STAT5a, LSD1 and HDAC3 target genes by ChIP-seq and RNA-seq revealed gene subsets regulated by independent or combined action of the factors and LSD1/HDAC3 to play dual role in their activation or repression. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL19057 GPL13112
27 Samples

Download data: TXT, XLSX

Series

Accession:: GSE79519

ID:: 200079519

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000795189.

The dual role of LSD1 and HDAC3 in STAT5-dependent transcription is determined by protein interactions, binding affinities, motifs and genomic positions [ChIP-seq]

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
13 Samples

Download data: BED, BEDGRAPH, XLSX

Series

Accession:: GSE79518

ID:: 200079518

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20004062410.

Genome-wide mapping of IL-2 regulated target genes and IL-2 activated STAT5 binding sites in Kit225 human leukemia cells.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by genome tiling array

Platforms:: GPL570 GPL5082
5 Samples

Download data: BAR, CEL, CHP, TXT

Series

Accession:: GSE40624

ID:: 200040624

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004061911.

Genome-Wide STAT5 binding sites in Kit225 leukemia cells

(Submitter supplied) In order to systematically map STAT5 genomic binding sites and IL-2 mediated gene expression changes we mapped STAT5 binding sites using chip-on-ChIP in IL-2 dependent Kit225 cells that were either left un-stimulated or stimulated with IL-2 for 30 minutes. Using MAT analysis we identified 1581 STAT5 binding sites.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL5082
1 Sample

Download data: BAR, CEL, CHP, TXT

Series

Accession:: GSE40619

ID:: 200040619

PubMed Full text in PMC Similar studies

Select item 20004061812.

IL-2 induced gene expression changes in Kit225 human leukemia cell lines

(Submitter supplied) Identify IL-2 mediated genes in Kit225 cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL570 GPL5082
5 Samples

Download data: BAR, CEL, CHP, TXT

Series

Accession:: GSE40618

ID:: 200040618

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007272413.

An autoregulatory enhancer controls mammary-specific STAT5 functions

(Submitter supplied) Signal Transducers and Activators of Transcription (STATs) are principal transcription factors downstream of cytokine receptors. Although STAT5A is expressed in most tissues it remains to be understood why its premier, non-redundant functions are restricted to prolactin-induced mammary gland development. We report that the ubiquitously expressed Stat5a/b locus is subject to lineage-specific transcriptional control in mammary epithelium. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
10 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE72724

ID:: 200072724

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010388614.

RRBS (reduced representation bisulfite sequencing) analysis of hepatocyte-specific STAT5a/STAT5b Knockout (STAT5ab-KO) mouse liver to identify differentially methylated regions (DMRs)

(Submitter supplied) The impact of STAT5 on liver DNA methylation was assessed by performing RRBS analysis on male and female mouse liver with a hepatocyte-specific loss of STAT5a and STAT5b. Extensive changes in CpG-methylation were seen in STAT5-deficient liver, where sex differences were abolished at 88% of ~1,500 sex-differentially methylated regions, largely due to increased DNA methylation upon STAT5 loss. STAT5-dependent CpG-hypomethylation was rarely found at proximal promoters of STAT5-dependent genes. more...

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL17021
23 Samples

Download data: XLSX

Series

Accession:: GSE103886

ID:: 200103886

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010388515.

Gene expression profiling of mouse liver with hepatocyte-specific knockout of STAT5a/STAT5b genes (STAT5ab-KO)

(Submitter supplied) rRNA-depleted RNA isolated from livers of control male and female mice and from male mice with hepatocyte-specific STAT5ab-KO was analyzed by RNA-seq. This study revealed a substantial, albeit incomplete loss of liver sex bias in hepatocyte-specific STAT5a/STAT5b (collectively, STAT5)-deficient mouse liver. Notably, in male liver, many male-biased genes were down regulated in direct association with the loss of STAT5 binding; many female-biased genes, which show low STAT5 binding, were de-repressed, indicating an indirect mechanism for repression by STAT5. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
8 Samples

Download data: XLSX

Series

Accession:: GSE103885

ID:: 200103885

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010231716.

STAT5-mediated chromatin interactions in superenhancers activate IL-2 highly inducible genes: Functional dissection of the Il2ra gene locus

(Submitter supplied) Cytokines critically control immune responses, but how regulatory programs are altered to allow T cells to differentially respond to distinct cytokine stimuli remains poorly understood. Here, we have globally analyzed enhancer elements bound by IL-2-activated STAT5 and IL-21-activated STAT3 in T cells and identified Il2ra as the top-ranked gene regulated by an IL-2-activated STAT5-bound superenhancer and one of the top genes regulated by STAT3-bound superenhancers. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL9250 GPL13112
28 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE102317

ID:: 200102317

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003498617.

Genome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes.

(Submitter supplied) Signal Transducers and Activators of Transcription (STAT) 5A/B regulate cytokine-inducible genes upon binding to GAS motifs. It is not known what percentage of genes with GAS motifs bind to and are regulated by STAT5. Moreover, it is not clear whether genome-wide STAT5 binding is modulated by its concentration. To clarify these issues we established genome-wide STAT5 binding upon growth hormone (GH) stimulation of wild type mouse embryonic fibroblasts (MEFs) and MEFs overexpressing STAT5A more than 20-fold. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
12 Samples

Download data: BED, BEDGRAPH

Series

Accession:: GSE34986

ID:: 200034986

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003368818.

Genome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes

(Submitter supplied) Stat5+/- mice were bred into the C57BL/6 background. Stat5+/- mice were intercrossed and mouse embryonic fibroblasts (MEFs) were isolated from 12.5-13.5-day WT or Stat5-/- fetuses. The retroviral-expression vector carrying a wild-type Stat5A gene based on an MSCV-IRES-GFP backbone (gift from Richard Moriggl, Ludwig-Boltzmann Institute, Vienna, Austria) was infected into Stat5-/- MEFs. FACS was used to select GFP+ cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
12 Samples

Download data: CEL, CHP

Series

Accession:: GSE33688

ID:: 200033688

PubMed Full text in PMC Similar studies Analyze with GEO2R

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