GEO DataSets

Analysis of T lymphocyte Jurkat cells treated with 10 nM azaspiracid-1 (AZA-1) for up to 24 hours. AZA-1 is a marine biotoxin reported to accumulate in shellfish and is associated with severe gastrointestinal human intoxication. Results provide insight into the mechanism of action of AZA-1.

Organism:

Homo sapiens

Type:

Expression profiling by array, log10 ratio, 3 time sets

Platform:

GPL1708

Series:

GSE5346

6 Samples

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(Submitter supplied) Human lymphocyte T cells in vitro were exposed to azaspiracid (1 or 10 nM) for 1, 4, or 24 hours. Time matched controls (methanol 0.1% v/v) was used.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3429

Platform:

GPL1708

9 Samples

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(Submitter supplied) Azaspiracid-1 (AZA-1) is a marine phycotoxin that accumulates in shellfish and known to cause severe gastrointestinal intoxications in humans. As the mechanism of action of AZA-1 is currently unknown, human DNA microarrays were used to profile gene expression in human lymphocyte T cells following AZA-1 exposure. Highly significant early (1 hr) genes consisted of a T cell specific transcription factor, membrane proteins, receptors, and inflammatory genes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3433

Platform:

GPL1708

6 Samples

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Analysis of T lymphocyte Jurkat cells treated with 1 or 10 nM azaspiracid-1 (AZA-1) for up to 24 hours. AZA-1 is a marine biotoxin reported to accumulate in shellfish and is associated with severe gastrointestinal intoxication. Results provide insight into the mechanism of action of AZA-1.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 2 dose, 3 time sets

Platform:

GPL1708

Series:

GSE8845

9 Samples

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(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) The alkylating agent N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) induces cellular DNA damages and other comprehensive alterations that lead to chromosomal aberrations, mutations, tumor initiations, and cell death. However, the molecular mechanism of MNNG-induced cellular stress remains unclear.We have genome-wide analyzed early transcriptional responses of human FL amnion epithelial cells after exposure to three relatively low doses of MNNG (0.2, 1.0, and 10.0µM),and differential gene expression profiles were obtained 4 h after exposure using oligonucleotide microarrays followed by validation with quantitative real-time RT-PCR. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL97

16 Samples

Download data: CEL, EXP

(Submitter supplied) To understand the host transcriptional response to S. enterica serovar Choleraesuis (S. Choleraesuis), the first generation Affymetrix porcine GeneChip® was used to identify differentially expressed genes in the mesenteric lymph nodes responding to infection at acute (8 hours (h), 24h, 48h post-inoculation (pi)) and chronic stages (21 days (d) pi) The objectives of this study were to identify and examine the stereotypical gene expression response within the host mesenteric lymph nodes to S. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL3533

15 Samples

Download data: CEL, EXP

(Submitter supplied) Gene expression profiles were performed from CD3+ T cells isolated from peripheral blood samples of untreated patients with cHL versus 2 control groups consisting of healthy donors and patients with sarcoidosis. Keywords = Hodgkin’s Lymphoma Keywords = T cell Keywords = immune regulation Keywords: repeat sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1419

Platform:

GPL8300

6 Samples

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Expression profiling of CD3+ T cells isolated from peripheral blood samples of untreated patients with classical Hodgkin's lymphoma. CD3+ T cells from healthy donors and patients with sarcoidosis also examined.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 disease state sets

Platform:

GPL8300

Series:

GSE2657

6 Samples

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