GEO DataSets

Analysis of gastric mucosa from H. pylori specific pathogen free (SPF) rhesus monkeys infected with wildtype H. pylori strain J166 or its isogenic cag pathogenicity island (cag PAI) knockout mutant. Results provide insight into the role of cag PAI in the H. pylori host-pathogen interaction.

Organism:

Macaca mulatta; Homo sapiens

Type:

Expression profiling by array, count, 4 infection, 3 time sets

Platform:

GPL201

Series:

GSE8749

32 Samples

Download data: CEL, CHP

(Submitter supplied) We used the rhesus macaque model to study the effects of the cag pathogenicity island (cag PAI) on the H. pylori host-pathogen interaction. Specific pathogen free (SPF) monkeys with no prior exposure to H. pylori were experimentally challenged with wild type (WT) H. pylori strain J166 (N=4) or its cag PAI isogenic knockout (KO, N=4). Animals underwent endoscopy before and 1, 4, 8, and 13 wks after challenge. more...

Organism:

Macaca mulatta; Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3434

Platform:

GPL201

32 Samples

Download data: CEL, CHP

(Submitter supplied) Interferons (IFNs) are thought to primarily protect against intracellular pathogens. Here we show that Helicobacter pylori, a chronic colonizer of gastric mucosal surfaces, effectively blocks both type I and type II IFN signalling via cholesterol-α-glucosyltransferase (CaGT). Thus, CaGT, causing depletion of cholesterol from host cells, prevents infected epithelial cells from executing crucial effector functions, including the production of human b-defensin 3 (hBD3). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

4 Samples

Download data: TXT

(Submitter supplied) TC1: gastric epithelial (AGS) cells infected with wild type H. pylori (G27) and isogenic mutants in cagA and vacA for 0, 0.5, 3, 6, and 12 hours. Total RNA was used to make single stranded Cy5 labelled probe and compared to Cy3 labelled probe from uninfected AGS cells. Hybridizations of G27 (trial 4) and cagA- (trial 3) timecourses were done in parallel. A technical replicate of the G27 time course (trial 5) and hybridization of vacA- (trial 3) time course were done in parallel. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

4 related Platforms

54 Samples

Download data

(Submitter supplied) Helicobacter pylori is a highly successful and important human pathogen that causes chronic gastritis, peptic ulcer diseases and gastric cancer. Innate immunity plays an important role of the primary defense against pathogens and epidemiological studies have suggested a role of toll-like receptor 1 (TLR1) in the risk of H. pylori acquisition. We performed microarray analysis of gastric mucosal biopsy specimens from H. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17077

32 Samples

Download data: TXT

(Submitter supplied) Carcinogenic bacteria, Helicobacter pylori, induce DNA double-strand breaks in infected host cells, while ATM-dependent DNA damage responses in host cells suppress genome instabilities caused by DNA breakages, which resulting in the suppression of H. pylori-induced gastric cancers. Although Helicobacter pylori infection is etiologically related to the inflammation-related malignancy, gastric cancers, it role in the molecular pathogenesis of disease remains unclear. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13497

16 Samples

Download data: TXT

(Submitter supplied) Carcinogenic bacteria, Helicobacter pylori, induce DNA double-strand breaks in infected host cells. Therefore, we have investigated which genes are upregulated after the infection. Although Helicobacter pylori infection is etiologically related to the inflammation-related malignancy, gastric cancers, it role in the molecular pathogenesis of disease remains unclear. In vitro studies have suggested the infection may cause breaks in double-stranded DNA. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17077

8 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL17077 GPL13497

24 Samples

Download data: TXT