Similar studies for GEO DataSets (Select 3469) - GEO DataSets

Select item 34691.

Analysis of monocytes following stimulation with leukotriene D4 (LTD4), a cysteinyl leukotriene (CysLT). CysLTs are mediators of innate immune responsiveness and chronic inflammatory diseases. Results provide insight into the signaling pathways involved in monocyte activation by cysLTs.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 4 individual sets

Platform:: GPL570
Series:: GSE7807
8 Samples

Download data: CEL

DataSet

Accession:: GDS3469

ID:: 3469

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000078072.

Leukotriene D4 induces gene expression in human monocytes through cysteinyl leukotriene type I receptor.

(Submitter supplied) Background: Cysteinyl leukotrienes (cysLTs) are important mediators of innate immune responsiveness and chronic inflammatory diseases. CysLTs acting through cysteinyl leukotriene receptors may influence the migration and activity of cells such as eosinophils, monocytes and dendritic cells. Objective: To determine the gene expression signature of human monocytes in response to cysLTs and to elucidate the signaling pathways involved in monocyte activation. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3469
Platform:: GPL570
8 Samples

Download data: CEL

Series

Accession:: GSE7807

ID:: 200007807

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000248693.

Cooperative and redundant signaling of leukotriene B4 and leukotriene D4 in human monocytes

(Submitter supplied) LTB4, 50 nmol/L for 30 minutes, induced expression of 27 genes in cultured human elutriated monocytes comparred to vehicle (ethanol) treated control cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
10 Samples

Download data: CEL

Series

Accession:: GSE24869

ID:: 200024869

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000437694.

Expression data from human Th1 and Th2 cells

(Submitter supplied) T-helper cells differentiate from naïve precursors into multiple lineages, including Th1, Th2, Th17 and inducible Treg, in humans and mice. The identification of each lineage is currently determined by examination of a small number of genes encoding hallmark cytokines and/or transcription factors in both species To gain a better understanding of human T-helper cell function we have performed detailed transcriptional profiling of highly polarized Th1 and Th2 cells in both resting and activated states examining gene and miRNA expression

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
12 Samples

Download data: CEL

Series

Accession:: GSE43769

ID:: 200043769

Select item 2000022895.

(dye reversal) wildtype CD4+ alpha beta T cells vs. LATY136F CD4+ alpha beta T cells

(Submitter supplied) color swap ratio profiles (dye-reversal) wildtype CD4+ alpha beta T cells vs. LATY136F CD4+ alpha beta T cells: GSM42565 and GSM42566 Keywords: repeat sample

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1868
2 Samples

Download data: TIFF

Series

Accession:: GSE2289

ID:: 200002289

Select item 2000022876.

(ratio exp) LAT3YF CD5+ gamma delta T cells

(Submitter supplied) ratio experiment by combining dye-reversal ratio profiles CD4+ alpha beta T cells were positively sorted from LatY136F or from wild-type spleen using a MACS and anti-CD4 beads. Gamma delta T cells were sorted from the spleen of Lat3YF and of Eb-/- mice using MACS and anti-CD5 beads. In vitro differentiated Th1 and Th2 cells were generated by culturing naive wild-type CD4+ T cells for 4 days in complete RPMI in the presence of anti-CD3 (1 µg/ml) plus anti-CD28 (1 µg/ml) with the addition of IL-12 (10ng/ml) and of anti-IL-4 (5µg/ml) for Th1-polarizing conditions, and of IL-4 (20ng/ml) plus anti-IFN-gamma (10µg/ml) for Th2-polarizing conditions. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1868
2 Samples

Download data: TIFF

Series

Accession:: GSE2287

ID:: 200002287

Select item 2000022867.

(ratio exp) LATY136F CD4+ alpha beta T cells

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1868
2 Samples

Download data: TIFF

Series

Accession:: GSE2286

ID:: 200002286

Select item 2000756038.

Leukotriene E4 is a full functional agonist for human cysteinyl leukotriene type 1 receptor

(Submitter supplied) Leukotriene E4 (LTE4) the most stable of the cysteinyl leukotrienes (cysLTs) binds poorly to classical type 1 (CysLT1) and 2 (CysLT2) receptors although it induces potent responses in human airways in vivo, such as bronchoconstriction, airway hyperresponsiveness and inflammatory cell influx suggesting the presence of a novel receptor that preferentially responds to LTE4. To identify such a receptor two human mast cell lines, LAD2 and LUVA, were selected that differentially responded to LTE4 when analysed by intracellular signalling and gene expression. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
15 Samples

Download data: CEL, TXT

Series

Accession:: GSE75603

ID:: 200075603

PubMed Full text in PMC Similar studies Analyze with GEO2R

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