GEO DataSets

Analysis of normal bronchial epithelial cells exposed to cigarette smoke from a typical light flavor brand for up to 24 hours. Results provide insight into the impact of cigarette smoke exposure at the molecular level.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 agent, 5 time sets

Platform:

GPL570

Series:

GSE10700

52 Samples

Download data: CEL, CHP

(Submitter supplied) Gene expression patterns were assessed in normal human bronchial epithelial (NHBE) cells exposed to cigarette smoke (CS) from a typical "full flavor" American brand of cigarettes in order to develop a better understanding of the genomic impact of tobacco exposure, which can ultimately define biomarkers that discriminate tobacco-related effects and outcomes in a clinical setting. NHBE cells were treated with CS for 15 minutes and alterations to the transcriptome assessed at 1,2,4 and 24 hours post-CS-exposure using high-density oligonucleotide microarrays. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3493

Platform:

GPL570

24 Samples

Download data: CEL, CHP

(Submitter supplied) Gene expression patterns were assessed in normal human bronchial epithelial (NHBE) cells exposed to cigarette smoke from a reference cigarette (2R4F, University of Kentucky) and a typical American brand of "light" cigarettes ("Lights") in order to develop a better understanding of the genomic impact of tobacco exposure, which can ultimately define biomarkers that discriminate tobacco-related effects and outcomes in a clinical setting. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3494

Platform:

GPL570

52 Samples

Download data: CEL, CHP

Analysis of normal bronchial epithelial cells exposed to cigarette smoke from a typical full flavor brand for up to 24 hours. Results provide insight into the impact of cigarette smoke exposure at the molecular level.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 4 time sets

Platform:

GPL570

Series:

GSE10718

24 Samples

Download data: CEL, CHP

(Submitter supplied) Bronchopulmonary dysplasia (BPD), a chronic lung disease of prematurity, has been linked to endoplasmic reticulum (ER) stress. To investigate a causal role for ER stress in BPD pathogenesis, we generated mice (cGrp78f/f) with lung epithelial cell-specific knockout (KO) of Grp78, a gene encoding the ER chaperone 78-kDa glucose-regulated protein (GRP78), a master regulator of ER homeostasis and the unfolded protein response (UPR). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

7 Samples

Download data: TXT

(Submitter supplied) Comparing genome-wide gene expression profiles of highly metastatic lung cancer cell line NCI-H460-LNM35 vs low metastatic parental clone NCI-H460-N15 Keywords: Expression profiling with cDNA microarray

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8725

4 Samples

Download data: TXT

(Submitter supplied) We compared gene and protein expression profiles in cells challenged with ER stress-inducing drugs or expressing model polypeptides. Drugs titration to limit up-regulation of the endogenous ER stress reporters BiP/HSPA5 and HERP/HERPUD1 to levels comparable to luminal accumulation of unfolded proteins substantially reduced the amplitude of transcriptional and translational responses.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

38 Samples

Download data: TXT

(Submitter supplied) Uromodulin is the most abundant urinary protein. It is exclusively produced and released in the urine by renal epithelial cells lining the thick ascending limb of Henle’s loop (TAL). Mutations in UMOD, the gene encoding uromodulin, cause autosomal dominant tubulointerstitial kidney disease uromodulin-related (ADTKD-UMOD). While the primary effect of all mutations, retention in the endoplasmic reticulum (ER), is well established, its downstream effects are still unknown. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL17021 GPL19057

6 Samples

Download data: FA, GTF, XLS