GEO DataSets

Analysis of skeletal muscles of 4 to 5 month old males treated with an anti-myostatin antibody to inhibit myostatin activity. Myostatin null mutations lead to hypermuscularity. Results provide insight into the molecular effect of the post-developmental loss of myostatin activity on skeletal muscles.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL1261

Series:

GSE13707

20 Samples

Download data: CEL

(Submitter supplied) More than 2,000 genes appear to be upregulated or downregulated in skeletal muscle of mice with constitutive knockout of myostatin (Steelman et al., FASEB J 20:580-2, 2006). This study was done to determine whether inhibition of myostatin activity in mature mice has similar effects on the pattern of gene expression. Keywords: Differential expression in treated and control mice

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3526

Platform:

GPL1261

20 Samples

Download data: CEL

(Submitter supplied) Phosphorylation of Ribosomal Protein S6 (RPS6) was the first post-translational modification of the ribosome to be identified and is a commonly-used readout for mTORC1 activity. Although the cellular and organismal functions of RPS6 phosphorylation are known, its molecular consequences on translation are less well understood. Here we use selective ribosome footprinting to analyze the location of ribosomes containing phosphorylated RPS6 on endogenous mRNAs in cells. more...

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL21697 GPL21626

7 Samples

Download data: XLSX

(Submitter supplied) RNA from 5 mice with postdevelopmental knockout of myostatin and 5 mice with normal myostatin expression was analyzed with comprehensive oligonucleotide microarrays. Myostatin depletion affected the expression of several hundred genes at nominal P < 0.01, but fewer than a hundred effects were statistically significant according to a more stringent criterion (false discovery rate < 5%). Most of the effects were less than 1.5-fold in magnitude. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3637

Platform:

GPL1261

10 Samples

Download data: CEL

Analysis of mature skeletal muscle depleted for the TBFb protein myostatin (MSTN). MSTN inhibits muscle differentiation and growth. MSTN deficiency during development results in muscle hypertrophy. Results provide insight into the effect of reducing MSTN activity after normal muscle development.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL1261

Series:

GSE15349

10 Samples

Download data: CEL