Similar studies for GEO DataSets (Select 3558) - GEO DataSets

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Items: 4

Select item 35581.

Deferasirox effect on leukemia cell line: dose response

Analysis of leukemia K562 cells treated with 10 or 50 uM deferasirox. Deferasirox is an iron chelator taken orally to treat iron toxicity. Iron depletion by deferasirox inhibits cancer cell proliferation in vitro. Results provide insight into the molecular basis of this anti-proliferative effect.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 3 dose sets

Platform:: GPL570
Series:: GSE11670
6 Samples

Download data: CEL

DataSet

Accession:: GDS3558

ID:: 3558

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000116702.

Transcriptional profiling of ICL670 treated K562 cells

(Submitter supplied) Iron plays a central role in the regulation of many cellular functions. Dysregulation of its metabolism leads an iron overload situation and iron depletion leads to an inhibition of cell proliferation. Recent reports demonstrated that ICL670 (Novartis) acts as a potent NF-kappa-B inhibitor and improves hematological data in a subset of MDS patients (Cilloni et al, Haematologica, s1: 238, 2007). However, the precise mechanism of anti-cancer effect of ICL670 is still uncertain. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3558
Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE11670

ID:: 200011670

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000813633.

Investigation of gene expression alterations of pancreatic cancer caused by Deferasirox administration

(Submitter supplied) To investigate the genetic effect of Deferasirox in pancreatic cancer, we examined gene expression alternations in the removed tumors exposed to Deferasirox.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17077
6 Samples

Download data: TXT

Series

Accession:: GSE81363

ID:: 200081363

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000323694.

Effect of iron chelators on global gene expression pattern in SW480 cells

(Submitter supplied) Gene expression analysis of SW480 cells treated with inhibitor compounds for 6 hours. Results provide insights into the role of iron in Wnt signalling and demonstrate that iron depletion is the primary mode of actions of these compounds on Wnt pathway.