GEO DataSets

Analysis of peripheral blood mononuclear cells from shoe factory workers exposed to benzene. Benzene is a leukemogen. Results provide insight into molecular mechanisms of benzene carcinogenicity.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL2700

Series:

GSE9569

16 Samples

Download data

(Submitter supplied) The effect of benzene exposure on peripheral blood mononuclear cell (PBMC) gene expression was examined in a population of shoe-factory workers with well-characterized occupational exposures to benzene. We compared data from two microarray platforms (Illumina and Affymetrix). Keywords: occupational exposure

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS3559 GDS3560 GDS3561

Platforms:

GPL96 GPL97 GPL2700

48 Samples

Download data: CEL, XLS

Analysis of peripheral blood mononuclear cells from shoe factory workers exposed to benzene. Benzene is a leukemogen. Results provide insight into molecular mechanisms of benzene carcinogenicity.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL97

Series:

GSE9569

16 Samples

Download data: CEL

Analysis of peripheral blood mononuclear cells from shoe factory workers exposed to benzene. Benzene is a leukemogen. Results provide insight into molecular mechanisms of benzene carcinogenicity.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL96

Series:

GSE9569

16 Samples

Download data: CEL

(Submitter supplied) Human toxicogenomic studies to date have been of limited size, have mainly addressed exposures at the upper end of typical ranges of human exposure, and have often lacked precise, individual estimates of exposure. Previously, we identified genes associated with exposure to high (>10 ppm) levels of the leukemogen, benzene, through transcriptomic analyses of blood cells from small numbers of occupationally exposed workers. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6104

144 Samples

Download data: TXT

(Submitter supplied) Previously, using microarrays and mRNA-Sequencing (mRNA-Seq) we found that occupational exposure to a range of benzene levels perturbed gene expression in peripheral blood mononuclear cells. In the current study, we sought to identify gene expression biomarkers predictive of benzene exposure below 1 part per million (ppm), the occupational standard in the U.S. First, we used the nCounter platform to validate altered expression of 30 genes in 33 unexposed controls and 57 subjects exposed to benzene (<1 to ≥5 ppm). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL25533

96 Samples

Download data: XLSX

(Submitter supplied) One of the top priorities of the swine industry worldwide is to decrease the susceptibility of its animals to infectious diseases. There is therefore now an increased focus on the production of more “robust” animals, which have lower susceptibility to a broad range of infectious diseases. One general measure of immune competence is the proliferative response of peripheral blood mononuclear cells (PBMC) to mitogenic stimulation. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL14897

24 Samples

Download data: GPR

(Submitter supplied) Up to date the studies examining the gene expression profiles in response to exposure to nickel compounds have only been conducted using in vitro tissue culture systems. Here, we have compared the gene expression profiles in peripheral blood mononuclear cells (PMCs) of eight nickel refinery workers in Jinchang, China to the expression profiles of referent subjects with only environmental exposure.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4974

Platform:

GPL6244

18 Samples

Download data: CEL

Analysis of peripheral blood mononuclear cells from 8 nickel refinery workers. Occupational exposure to nickel is associated with an increased risk of lung and nasal cancers. Results provide insight into molecular mechanisms underlying nickel carcinogenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 stress sets

Platform:

GPL6244

Series:

GSE40392

18 Samples

Download data: CEL

(Submitter supplied) Microarrays have been widely used for the analysis of gene expression and several commercial platforms are available. The combined use of multiple platforms can overcome the inherent biases of each approach, and may represent an alternative that is complementary to RT-PCR for identification of the more robust changes in gene expression profiles. In this paper, we combined statistical and functional analysis for the cross platform validation of two oligonucleotide-based technologies, Affymetrix (AFFX) and Applied Biosystems (ABI), and for the identification of differentially expressed genes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL570 GPL1426

12 Samples

Download data: CEL

(Submitter supplied) The growth in popularity of RNA expression microarrays has been accompanied by concerns about the reliability of the data especially when comparing between different platforms. Here we present an evaluation of the reproducibility of microarray results using two platforms, Affymetrix GeneChips and Illumina BeadArrays. The study design is based on a dilution series of two human tissues (blood and placenta), tested in duplicate on each platform. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL2725 GPL570

24 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL6097 GPL570

20 Samples

Download data: CEL, TXT

(Submitter supplied) The present study was conducted to compare the ability of Affymetrix and Illumina microarray technologies to characterize the differential gene expression profiles of human monocytes and monocyte-derived-macrophages. Keywords: Type Cross-platform comparison Summary

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3554

Platform:

GPL570

10 Samples

Download data: CEL

(Submitter supplied) In this study we analyzed the gene expression profiles of human monocytes and monocyte-dervied-macrophages. Keywords: Gene expression profiling

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3553

Platform:

GPL1946

96 Samples

Download data: GPR

(Submitter supplied) The present study was conducted to compare the ability of Affymetrix and Illumina microarray technologies to characterize the differential gene expression profiles of human monocytes and monocyte-derived-macrophages. Keywords: Cross-platform comparison

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3555

Platform:

GPL6097

10 Samples

Download data: TXT

Comparison of monocytes and macrophages. Samples obtained from patients with acute coronary syndrome. Results compared to the performance of Affymetrix arrays (GDS3554). The result from two-color arrays (GDS3553) was used as a reference for the Illumina and Affymetrix arrays.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 cell type, 5 individual sets

Platform:

GPL6097

Series:

GSE10213

10 Samples

Download data: TXT

Comparison of monocytes and macrophages. Samples obtained from patients with acute coronary syndrome. Results compared to the performance of Illumina arrays (GDS3555). The result from two-color arrays (GDS3553) was used as a reference for the Illumina and Affymetrix arrays.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 cell type, 5 individual sets

Platform:

GPL570

Series:

GSE11430

10 Samples

Download data: CEL

Comparison of monocytes and macrophages. Samples obtained from 86 patients with acute coronary syndrome. Results used as a reference to compare the performance of Affymetrix (GDS3554) and Illumina (GDS3555) arrays.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 2 cell type, 48 individual, 2 protocol sets

Platform:

GPL1946

Series:

GSE10220

96 Samples

Download data: GPR

(Submitter supplied) Exposure to Polychlorobiphenyls (PCBs) is known to cause serious health effects in human but the gene expression profiles leading to development of differnet diseases and disorders are not fully understood. The knowledge of global gene expression will help us to devlop early disease or disorder biomarkers for PCB induced health effects. We used microarrays to detail the global gene expression profile underlying the effects of mixed PCB exposure at Slovak Human equivalance Level on human PBMC leading to identification of distinct classes of up-regulated and down-regulated genes and cellular processes.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

12 Samples

Download data: CEL

(Submitter supplied) We developed a method to convert gene expression signatures across the Illumina and Affymetrix platforms.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL571 GPL10558

83 Samples

Download data: CEL