GEO DataSets

Analysis of normal lung WI-38 fibroblasts exposed to various concentrations of the carcinogen benzo[a]pyrene diol epoxide (BPDE). BPDE is a metabolite of benzo[a]pyrene, a component of cigarette smoke. Results provide insight into the molecular response of normal lung fibroblasts to BPDE.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 4 dose sets

Platform:

GPL570

Series:

GSE19510

14 Samples

Download data: CEL

(Submitter supplied) Cellular responses to carcinogens are typically studied in transformed cell lines, which do not reflect the physiological status of normal tissues. To address this question, we have characterized the transcriptional program and cellular responses of normal human lung WI-38 fibroblasts upon exposure to the ultimate carcinogen benzo[a]pyrene diol epoxide (BPDE). Exposure to BPDE induces a strong inflammatory response in WI-38 primary fibroblasts. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3706

Platform:

GPL570

14 Samples

Download data: CEL

(Submitter supplied) Human colon carcinoma cells (HCT116) differing in p53 status were exposed to benzo(a)pyrene (BaP) (2.5 and 5 uM for up to 48 h) or anti-benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide (BPDE)(0.5 and 1 uM for up to 24 h), and their gene expression responses compared by cDNA microarray technology. Keywords: BaP or BPDE exposure

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4348

47 Samples

Download data: GPR

(Submitter supplied) The environmental carcinogen, (±)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), causes bulky-adduct DNA damages, triggers certain signaling pathways, and elicits gene expression changes. Here, we focused on the temporal gene expression changes induced by a low concentration (0.05 µM) BPDE in human amnion epithelial FL cells. Differential gene expression profiles at 1, 10 and 22 h post BPDE treatment were obtained using Affymetrix HG-U133 Plus 2.0 oligonucleotide microarrays. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

18 Samples

Download data: CEL, EXP