Similar studies for GEO DataSets (Select 4101) - GEO DataSets

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Items: 2

Select item 41011.

Response of pancreatic and colorectal cancer cells to CD24 down-regulation by monoclonal antibody or small interfering RNA

Analysis of HT29 and Colo357 cancer cell lines following treatment with anti-CD24 mAbs, and HT29 cells after expression of 1 or 2 shRNA vectors directed at the CD24 gene. CD24 is overexpressed in a large variety of human malignancies. Results provide insight into the role of CD4 in carcinogenesis.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 5 agent, 2 cell line sets

Platform:: GPL571
Series:: GSE15102
8 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS4101

ID:: 4101

Select item 2000151022.

Targetting CD24 for treatment of colorectal and pancreatic cancer by monoclonal antibodies or siRNA

(Submitter supplied) CD24 is a potential oncogene reported to be overexpressed in a large variety of human malignancies. We have shown that CD24 is overexpressed in 90% of colorectal tumors at a fairly early stage in the multistep process of carcinogenesis. Anti-CD24 monoclonal antibodies (mAb) induce a significant growth inhibition in colorectal and pancreatic cancer cell lines that express the protein. This study is designed to investigate further the effects of CD24 down-regulation using mAb or small interfering RNA in vitro and in vivo. more...