GEO DataSets

Analysis of hippocampal cornu ammonis and dentate gyrus from young and aged female simians. Aging rhesus monkeys develop Metabolic Syndrome (MetS) symptoms and age-related cognitive decline similar to humans. Results provide insight into MetS-associated brain dysfunction in aging.

Organism:

Macaca mulatta

Type:

Expression profiling by array, count, 2 age, 2 tissue sets

Platform:

GPL3535

Series:

GSE11697

23 Samples

Download data: CEL

(Submitter supplied) Metabolic, mitochondrial and behavioral correlations with transcriptional profiles from the CA1 and DG hippocampal regions of young and aged rhesus macaque. Increasing evidence indicates that obesity correlates with impaired cognitive performance during normal aging and is a major risk factor for Alzheimer’s disease. However, little is known regarding how peripheral metabolic variables affect cellular pathways in brain regions important for memory. more...

Organism:

Macaca mulatta

Type:

Expression profiling by array

Dataset:

GDS4215

Platform:

GPL3535

23 Samples

Download data: CEL, PDF

(Submitter supplied) Gene expression was measured from the dentate gyrus and entorhinal cortex harvested from human postmortem samples.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

16 Samples

Download data

(Submitter supplied) Previous studies of age-related transcriptional changes indicate that cognitive impairments are associated with differentially expressed genes DEGs linked to defined neural systems; however, studies that examine multiple regions of the hippocampus fail to find major links between behavior and transcription in the dentate gyrus DG. The DG is implicated in pattern separation PS and exhibits multiple age-related changes that may affect PS performance. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL19482 GPL27757

84 Samples

Download data: CSV

(Submitter supplied) Aging is associated with a decline in hippocampal mediated learning and memory, a process wich can be ameliorated by dietary (caloric) restriction. We used Affymetrix gene expression analysis to monitor changes in three regions of the hippocampus (CA1, CA3, DG) of middle aged (18 months) and old (28 month) rats that were exposed to dietary restriction. Old rats were determined to be good performers (GP) or poor performers (PP) in behavioral tests to assess thier hippocampal function.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

45 Samples

Download data: CEL, CHP, TXT, XLS

(Submitter supplied) The project examined age-related change in hippocampal gene expression in Fisher 344 x Brown Norway F1 rats from the NIA aging colony (Adult = 12M, Aged = 24M). CA1, CA3, and DG specific dissections were examined from one cohort of animals and from a second cohort whole hippocampus was used.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6101

60 Samples

Download data: TXT

(Submitter supplied) Recent microarray studies in the hippocampus of rodents or Alzheimer’s disease (AD) subjects have identified a substantial number of cellular pathways/processes correlated with aging and cognitive decline. However, the temporal relationships among these expression changes or with cognitive impairment have not been studied in depth. Here, using Affymetrix microarrays, immunohistochemistry and Morris water maze cognitive testing across 5 age groups of male F344 rats (n=9-15/group, one microarray per animal), we systematically analyzed the temporal sequence and cellular localization of aging changes in expression. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3915

Platform:

GPL341

49 Samples

Download data: CEL

Analysis of hippocampi from F344 males, at 5 age points across the adult lifespan, tested on the Morris water maze (MWM) task. MWM is a dorsal hippocampal-dependent, spatial memory task. MWM performance showed an age effect. Results provide insight into the molecular basis of cognitive aging.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 5 age sets

Platform:

GPL341

Series:

GSE9990

49 Samples

Download data: CEL

(Submitter supplied) Caloric restriction (CR) is one of the most robust interventions shown to delay aging in diverse species, including rhesus monkeys (Macaca mulatta). Identification of factors involved in CR brings a promise of translatability to human health and aging. Here, we show that CR induced a profound change in abundance of circulating microRNAs (miRNAs) linked to growth and insulin signaling pathway, suggesting that miRNAs are involved in CR’s mechanisms of action in primates. more...

Organism:

Macaca mulatta

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL14954

10 Samples

Download data: TXT

(Submitter supplied) This dataset contains microarray data from normal controls (aged 20-99 yrs) and Alzheimer's disease cases, from 4 brain regions: hippocampus, entorhinal cortex, superior frontal cortex, post-central gyrus. Changes in expression of synaptic and immune related genes were analyzed, investigating age-related changes and AD-related changes, and region-specific patterns of change. These AD cases were processed simultaneously with the control cases (young and aged) included in GSE11882 (GSE11882 dataset contains data exclusively from normal control brains).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

253 Samples

Download data: CEL

(Submitter supplied) This dataset of cognitively normal controls is a subset of the GSE48350 dataset, which additionally contains microarray data from AD brains. Gene expression profiles were assessed in the hippocampus (HC), entorhinal cortex (EC), superior frontal gyrus (SG), and postcentral gyrus (PCG) across the lifespan of 63 cognitively intact individuals from 20-99 years old. New perspectives on the global gene changes that are associated with brain aging emerged, revealing two overarching concepts. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

173 Samples

Download data: CEL

(Submitter supplied) Although immediate early genes (IEGs) such as Bdnf, Arc and Egr1, have been implicated in plasticity, the larger pathways related to memory and memory disorders are not well understood. Here, we combined statistical Affymetrix microarray and behavioral analyses to identify key genes and pathways associated with aging-related cognitive impairment. Aged rats were separated into cognitively unimpaired (AU) or impaired (AI) groups, based on their Morris water maze performance relative to young-adult (Y) animals. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2639

Platform:

GPL341

78 Samples

Download data: CEL, EXP, XLS

Analysis of hippocampi from aged learning-impaired animals on the last day of training in the Morris water maze (MWZ) or 21 days post-training. The MWZ task is a dorsal hippocampal-dependent task. Results provide insight into the molecular basis of aging-related cognitive impairment.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 age, 3 disease state, 3 protocol sets

Platform:

GPL341

Series:

GSE5666

78 Samples

Download data: CEL, EXP