Similar studies for GEO DataSets (Select 4332) - GEO DataSets

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Items: 2

Select item 43321.

Interleukin 1β effect on insulinoma cell line overexpressing pancreatic duodenum homeobox 1: time course

Analysis of pancreatic duodenum homeobox 1 (Pdx1)-overexpressing, INS-1ab insulinoma cell line exposed to Interleukin 1b (IL-1β) cytokine for up to 24 hrs. Results provide insight into the molecular mechanisms underlying Pdx1-driven potentiation of beta cell sensitivity to IL-1β.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 agent, 2 genotype/variation, 5 time sets

Platform:: GPL1355
Series:: GSE40642
56 Samples

Download data: CEL

DataSet

Accession:: GDS4332

ID:: 4332

Select item 2000406422.

Pdx1 overexpression sensitizes to IL-1b-induced apoptosis

(Submitter supplied) Cytokines have been shown to play a key role in the destruction of beta cells. In the rat insulinoma cell line (INS-1ab) overexpressing pancreatic duodenum homeobox 1 (Pdx1) increases sensitivity to Interleukin 1b (IL-1b). To elucidate mechanisms of action underlying Pdx1 driven potentiation of beta-cell sensitivity to IL-1β, we performed a microarray analysis of INS-1ab cells with and without Pdx1 overexpression exposed to IL-1β between 2h and 24h.