GEO DataSets

Analysis of pancreatic CD45+ cells from 10 week-old NOD females MRI-scanned to noninvasively visualize effects of pancreatic-islet inflammation. All NOD juveniles develop insulitis but vary highly in their progression to diabetes. Results provide insight into molecular basis of disease progression.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 5 individual sets

Platform:

GPL6246

Series:

GSE35096

5 Samples

Download data: CEL

(Submitter supplied) The aim of this study was to explore what molecular and cellular processes predicate the conversion from insulitis to diabetes. The transcriptional profiles of CD45+ immune cells collected from pancreas of a cohort of age-matched female mice, which were scanned by MRI to determine the risk of diabetes development.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4347

Platform:

GPL6246

5 Samples

Download data: CEL

(Submitter supplied) We profile the transcriptomes of over 100,000 human single cells, yielding molecular definitions for non-parenchymal cell types present in healthy and cirrhotic human liver. We uncover a novel scar-associated TREM2+CD9+ macrophage subpopulation, which expands in liver fibrosis, differentiates from circulating monocytes, has a corollary population in mouse liver fibrosis and is pro-fibrogenic. We also define novel ACKR1+ and PLVAP+ endothelial cells which expand in cirrhosis, are topographically scar-restricted and enhance leucocyte transmigration. more...

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL21103 GPL20301

26 Samples

Download data: MTX, TSV

(Submitter supplied) We demonstrate diverse roles of interferon–gamma (IFN-γ) in the induction and regulation of immune-mediated inflammation using a transfer model of autoimmune diabetes. The diabetogenic CD4+BDC2.5 (BDC) T cell clone upon transfer into NOD.scid mice induced destruction of islets of Langerhans leading to diabetes. Administration of a neutralizing antibody to IFN-γ (H22) resulted in long term protection (LTP) from diabetes, with inflammation but persistence of a significant, albeit decreased numbers of β-cells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4034

Platform:

GPL1261

8 Samples

Download data: CEL

Temporal analysis of microdissected islets of NOD.Scid mice injected with diabetogenic CD4+BDC2.5 (BDC) T cells, then injected with anti-interferon-γ monoclonal antibody which protected the mice from developing diabetes. Results provide insight into the role of INF-γ role in autoimmune diabetes.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 2 protocol, 5 time sets

Platform:

GPL1261

Series:

GSE12389

8 Samples

Download data: CEL