Similar studies for GEO DataSets (Select 4385) - GEO DataSets

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Items: 5

Select item 43851.

CD133-positive and CD133-negative colon cancer cells

Analysis of CD133-positive and CD133-negative colorectal cancer cells and CAFs isolated from the same stage II patient specimen. CD133+ colon cancer cells exhibit enhanced tumorigenicity over CD133- cells. Results provide insight into molecular basis of the enhanced tumorigenicity of CD133+ cells.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 cell type sets

Platform:: GPL570
Series:: GSE34053
9 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS4385

ID:: 4385

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000340532.

CD133+ colon cancer cells are more interactive with the tumor microenvironment than CD133- cells

(Submitter supplied) CD133-positive colorectal cancer cells exhibit enhanced tumorigenicity over CD133-negative cells. The CD133+ cells are more interactive with and responsive to their stromal microenvironment because they also express the cognate receptors, such as CXCR4, for ligands produced by their neighboring carcinoma-associated fibroblasts, such as SDF-1 (stromal-derived growth factor).

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4385
Platform:: GPL570
9 Samples

Download data: CEL, CHP

Series

Accession:: GSE34053

ID:: 200034053

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000354783.

Characterization of colon cancer cells: a functional approach characterizing CD133 as a potential stem cell marker

(Submitter supplied) Background: Isolation and characterization of tumourigenic colon cancer initiating cells may help to develop novel diagnostic and therapeutic procedures. Methods: We characterized a panel of fourteen human colon carcinoma cell lines and their corresponding xenografts for the surface expression of different potential stem cell markers: CD133, CD24, CD44, CDCP1 and CXCR4. In five cell lines and nine xenografts mRNA expression of the investigated markers was determined. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
15 Samples

Download data: CEL

Series

Accession:: GSE35478

ID:: 200035478

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000173864.

CD133- HCC cells infected with miR-130b vs. empty vector control

(Submitter supplied) To identify candidate downstream mRNA target for hsa-miR-130b

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
2 Samples

Download data: CEL, CHP

Series

Accession:: GSE17386

ID:: 200017386

Select item 2000400175.

The disparate twins: A comparative study of CXCR4 and CXCR7 in SDF-1α-induced gene expression, invasion and chemosensitivity of colon cancer

(Submitter supplied) In colorectal cancer, increased expression of the CXC chemokine receptor 4 (CXCR4) has been shown to provoke metastatic disease due to the interaction with its ligand stromal cell-derived factor 1 (SDF-1). Recently, a second SDF-1 receptor, CXCR7, was found to enhance tumor growth in solid tumors. Albeit signaling cascades via SDF-1/CXCR4 have been intensively studied, the significance of the SDF-1/CXCR7-induced intracellular communication triggering malignancy is still only marginally understood. more...