Similar studies for GEO DataSets (Select 4388) - GEO DataSets

Select item 43881.

Leukemia inhibitory factor effect on Sin3a-silenced MCF7 breast cancer cell line

Analysis of SIN3 transcription regulator homolog A (Sin3a)-depleted MCF7 cells stimulated with LIF cytokine to activate signal transducer and activator of transcription 3 (STAT3). STAT3 transcription factor is a potent oncogene. Results provide insight into role of Sin3a in mediating STAT3 activity.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:: GPL570
Series:: GSE35696
11 Samples

Download data: CEL

DataSet

Accession:: GDS4388

ID:: 4388

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000356962.

SIN3A-regulated LIF-responsive genes in MCF7 cells

(Submitter supplied) Tyrosine phosphorylation is a hallmark for activation of Signal Transducer and Activator of Transcription (STAT) proteins, but their transcriptional activity also depends on other secondary modifications. Type I interferons (IFNs) can activate both the ISGF3 (STAT1:STAT2:IRF9) complex and STAT3, but with cell-specific, selective triggering of only the ISGF3 transcriptional program. Following a genome-wide RNAi screen, we identified the Sin3a complex as an important mediator of this STAT3 transcriptional repression. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4388
Platform:: GPL570
11 Samples

Download data: CEL

Series

Accession:: GSE35696

ID:: 200035696

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000380963.

Murine Testes: Germ Cell-Specific Sin3a Knockout vs. Hemizygous vs. Wild Type at Postnatal Day 0

(Submitter supplied) Chromatin modifier Swi-independent 3a (SIN3A), together with associated histone deacetylases, influences gene expression during development and differentiation through multiple transcription factors in a cell-specific manner. Sin3a is essential for the maintenance of inner cell mass cells of mouse blastocysts, embryonic fibroblasts, and myoblasts, but is not required for the survival of trophectoderm or Sertoli cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
6 Samples

Download data: TXT

Series

Accession:: GSE38096

ID:: 200038096

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000500074.

STAT2 and IRF9-dependent IFN-I signaling restores ISRE-mediated transcription and anti-viral activity independent of STAT1

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL15097 GPL10904
40 Samples

Download data

Series

Accession:: GSE50007

ID:: 200050007

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Select item 2000495255.

STAT2 and IRF9-dependent IFN-I signaling restores ISRE-mediated transcription and anti-viral activity independent of STAT1 (mouse)

(Submitter supplied) Type I Interferons (IFN-I) mediate cellular responses to virus infection. IFN-I induces IFN-stimulated gene (ISG) expression by phosphorylating STAT1 and STAT2, and together with interferon regulatory factor (IRF9), form the transcription complex ISGF3 that binds to the interferon-stimulated response element (ISRE) in ISG promoters. As a component of ISGF3, it is clear that STAT2 plays an essential role in the transcriptional responses to IFN-I with a strong dependence on STAT1. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL15097
16 Samples

Download data: TXT

Series

Accession:: GSE49525

ID:: 200049525

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000483136.

STAT2 and IRF9-dependent IFN-I signaling restores ISRE-mediated transcription and anti-viral activity independent of STAT1 (human)

(Submitter supplied) Type I Interferons (IFN-I) mediate cellular responses to virus infection. IFN-I induce IFN stimulated gene (ISG) expression by phosphorylating STAT1 and STAT2, and together with interferon regulatory factor (IRF)9, form the transcription complex ISGF3 that binds to the interferon-stimulated response element (ISRE) in ISG promoters. As a component of ISGF3 it is clear that STAT2 plays an essential role in the transcriptional responses to IFN-I with a strong dependence on STAT1. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10904
24 Samples

Download data: TXT

Series

Accession:: GSE48313

ID:: 200048313

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000339137.

IKK-epsilon regulates the balance between the type I and type II interferon responses

(Submitter supplied) Virus infection induces the production of type I and type II interferons (IFN-I and IFN-II), cytokines that mediate the antiviral response. IFN-I (IFN-a and -b) induces the assembly of ISGF3 (interferon-stimulated gene factor 3), a multimeric transcriptional activation complex comprised of STAT1, STAT2 and IRF9. IFN-II (IFN-g) induces the homodimerization of STAT1 to form the GAF (gamma-activated factor) complex. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11002
12 Samples

Download data: BED

Series

Accession:: GSE33913

ID:: 200033913

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000225548.

Genome-wide maps of Sin3A and Sin3B binding in C2C12 myoblasts and differentiated myotubes

(Submitter supplied) Sin3A and Sin3B bind to distinct and overlapping target sites. Sin3 proteins bind to distinct sites in cycling myoblasts whereas there is a converge of Sin3A and Sin3B proteins to sites in differentiated myotubes. We identified a subset of Sin3 target genes involved in muscle differentiation and physiology and showed that conditional ablation of Sin3 proteins in vivo in mouse results in sarcomere defects

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9185
14 Samples

Download data: BED

Series

Accession:: GSE22554

ID:: 200022554

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000199889.

Six1 and Six4 function in myoblast differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
32 Samples

Download data: TXT

Series

Accession:: GSE19988

ID:: 200019988

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Select item 20001996810.

Gene Expression Profiling of C2C12 Myoblast Differentiation

(Submitter supplied) In this study, the C2C12 cell line, a model used to study myogenesis and regeneration, was allowed to differentiate from myoblast precursor cells to myotubes. Cells were harvested at 4 different timepoints to perform gene expression profiling. We identified genes that were up-regulated and down-regulated during the differentiation process.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
12 Samples

Download data: TXT

Series

Accession:: GSE19968

ID:: 200019968

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001996711.

Gene Expression Profiling of siRNA Knock-Down of Six1, Six4 and Myogenin in C2C12

(Submitter supplied) Six1, Six4 and Myogenin are transcription factors that are known to be required for skeletal myogenesis. Currently, very little is known about the genes targeted by Six1 and Six4. Gene expression profiling when one or both transcription factors were knock-down by siRNA was performed to identify genes affected by their absence. We also hypothesized that Six1 and Six4 can work in cooperation with the myogenic regulatory factor (MRFs) family of transcription factors, such as Myogenin. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
20 Samples

Download data: TXT

Series

Accession:: GSE19967

ID:: 200019967

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Select item 20010324512.

Genome-wide mapping of SIN3A binding sites by ChIP-seq in HUVEC exposed to hypoxia

(Submitter supplied) Cells adapt to environmental changes, including fluctuations in oxygen levels, through the induction of specific gene expression programs. To identify genes regulated by hypoxia at the transcriptional level, we pulse-labeled HUVEC cells with 4-thiouridine and sequenced nascent transcripts. Then, we searched genome-wide binding profiles from the ENCODE project for factors that correlated with changes in transcription and identified binding of several components of the Sin3A co-repressor complex, including SIN3A, SAP30 and HDAC1/2, proximal to genes repressed by hypoxia. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
4 Samples

Download data: BEDGRAPH

Series

Accession:: GSE103245

ID:: 200103245

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20008984113.

Transcriptional repression in hypoxia is mediated by the Sin3A histone deacetylase complex

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

5 related Platforms
50 Samples

Download data: BEDGRAPH, BW, TXT

Series

Accession:: GSE89841

ID:: 200089841

PubMed Full text in PMC Similar studies

Select item 20008984014.

Transcriptional repression in hypoxia is mediated by the Sin3A histone deacetylase complex [RNA-seq]

(Submitter supplied) Cells adapt to environmental changes, including fluctuations in oxygen levels, through the induction of specific gene expression programs. To identify genes regulated by hypoxia at the transcriptional level, we pulse-labeled HUVEC cells with 4-thiouridine and sequenced nascent transcripts. Then, we searched genome-wide binding profiles from the ENCODE project for factors that correlated with changes in transcription and identified binding of several components of the Sin3A co-repressor complex, including SIN3A, SAP30 and HDAC1/2, proximal to genes repressed by hypoxia. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
8 Samples

Download data: TXT

Series

Accession:: GSE89840

ID:: 200089840

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20008983915.

Hypoxic regulation of gene expression in HUVEC is dominated by EPAS1

(Submitter supplied) Cells adapt to environmental changes, including fluctuations in oxygen levels, through the induction of specific gene expression programs. To identify genes regulated by hypoxia at the transcriptional level, we pulse-labeled HUVEC cells with 4-thiouridine and sequenced nascent transcripts. Then, we searched genome-wide binding profiles from the ENCODE project for factors that correlated with changes in transcription and identified binding of several components of the Sin3A co-repressor complex, including SIN3A, SAP30 and HDAC1/2, proximal to genes repressed by hypoxia. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
8 Samples

Download data: TXT

Series

Accession:: GSE89839

ID:: 200089839

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20008983816.

Hypoxic regulation of transcription in HUVEC is mediated by EPAS1

(Submitter supplied) Cells adapt to environmental changes, including fluctuations in oxygen levels, through the induction of specific gene expression programs. To identify genes regulated by hypoxia at the transcriptional level, we pulse-labeled HUVEC cells with 4-thiouridine and sequenced nascent transcripts. Then, we searched genome-wide binding profiles from the ENCODE project for factors that correlated with changes in transcription and identified binding of several components of the Sin3A co-repressor complex, including SIN3A, SAP30 and HDAC1/2, proximal to genes repressed by hypoxia. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18460
8 Samples

Download data: TXT

Series

Accession:: GSE89838

ID:: 200089838

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20008983617.

Genome-wide mapping of HIF binding sites by ChIP-seq in HUVEC cells exposed to hypoxia

(Submitter supplied) Cells adapt to environmental changes, including fluctuations in oxygen levels, through the induction of specific gene expression programs. To identify genes regulated by hypoxia at the transcriptional level, we pulse-labeled HUVEC cells with 4-thiouridine and sequenced nascent transcripts. Then, we searched genome-wide binding profiles from the ENCODE project for factors that correlated with changes in transcription and identified binding of several components of the Sin3A co-repressor complex, including SIN3A, SAP30 and HDAC1/2, proximal to genes repressed by hypoxia. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
4 Samples

Download data: BW

Series

Accession:: GSE89836

ID:: 200089836

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20008983118.

Metabolic Labeling of Newly Transcribed RNA for High Resolution Gene Expression Profiling of RNA Synthesis and Decay in response to hypoxia in HUVEC cells

(Submitter supplied) Cells adapt to environmental changes, including fluctuations in oxygen levels, through the induction of specific gene expression programs. To identify genes regulated by hypoxia at the transcriptional level, we pulse-labeled HUVEC cells with 4-thiouridine and sequenced nascent transcripts. Then, we searched genome-wide binding profiles from the ENCODE project for factors that correlated with changes in transcription and identified binding of several components of the Sin3A co-repressor complex, including SIN3A, SAP30 and HDAC1/2, proximal to genes repressed by hypoxia. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL10999
18 Samples

Download data: TXT

Series

Accession:: GSE89831

ID:: 200089831

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20009378119.

FOXN3 Enlists NEAT1-containing SIN3A Complex to Regulate Mammary Epithelium Differentiation and Promote Breast Cancer Metastasis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing; Non-coding RNA profiling by array

Platforms:: GPL20115 GPL23227
9 Samples

Download data: BW, TXT

Series

Accession:: GSE93781

ID:: 200093781

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20009378020.

FOXN3 and SIN3A ChIP-Seq; FOXN3 and IgG iRIP-Seq

(Submitter supplied) The forkhead box (FOX) family of proteins is composed of more than 50 members that are phylogenetically classified into 19 subclasses (A to S). These transcription factors all share a homology in their DNA-binding domain, the forkhead domain, also known as winged helix due to its butterfly-like structural appearance.FOX proteins have been implicated in a broad spectrum of cellular processes including cell proliferation, differentiation, DNA repair, metabolism, and aging. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL23227
7 Samples

Download data: BED, BW

Series

Accession:: GSE93780

ID:: 200093780

PubMed Full text in PMC Similar studies SRA Run Selector

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