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Links from GEO DataSets

Items: 2

1.
Full record GDS4482

Sonic Hedgehog inhibitor cyclopamine effect on co-culture of mesenchymal stem cells and umbilical vein endothelial cells

Analysis of a co-culture of 92% human mesenchymal stem cells (hMSC) and 8% human umbilical vein endothelial cells (huvEC) treated with the Sonic Hedgehog morphogen inhibitor cyclopamine. The co-culture of hMSC and huvEC supports the formation of a primitive three dimensional vascular network.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent sets
Platform:
GPL10526
Series:
GSE22293
6 Samples
Download data: CEL
2.

Engineering endochondral ossification using Sonic Hedgehog for bone regeneration

(Submitter supplied) Endochondral ossification (EO) is the natural route for the regeneration of large and mechanically challenged bone defects. Regeneration occurs via a fibrocartilagenous phase which turns into bone upon vascularization and the formation of a transient collagen type X extra cellular matrix. These two critical initiator of EO are mediated by Hedgehog proteins. We investigated a tissue engineering approach using Sonic Hedgehog (Shh) as a pleiotropic factor regulating the in vitro formation of a vascularized bone tissue precursor for in vivo endochondral bone formation. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4482
Platform:
GPL10526
6 Samples
Download data: CEL
Series
Accession:
GSE22293
ID:
200022293

Supplemental Content

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