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Links from GEO DataSets

Items: 9

1.
Full record GDS4802

WTX overexpression effect on kidney cell line

Analysis of HEK293 embryonic kidney cells overexpressing WTX, a tumor suppressor frequently inactivated in Wilms tumor. Ectopic expression of WTX in HEK293 cells activates p53 through lysine acetylation. Results provide insight into a role for WTX in the regulation of p53 activity.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL570
Series:
GSE34715
4 Samples
Download data: CEL, CHP
2.

Gene expression profiling after induction of WTX in HEK293 cells

(Submitter supplied) WTX encodes a tumor suppressor, frequently inactivated in Wilms tumor, with both plasma membrane and nuclear localization. WTX has been implicated in beta-catenin turnover, but its effect on nuclear proteins is unknown. We report an interaction between WTX and p53, derived from the unexpected observation of WTX, p53 and E1B 55K colocalization within the characteristic cytoplasmic body of adenovirus-transformed kidney cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4802
Platform:
GPL570
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE34715
ID:
200034715
3.

WTX interacts with the transcriptional regulator TRIM28 to mediate cellular differentiation

(Submitter supplied) WTX encodes a tumor suppressor implicated in Wilms tumor and in mesenchymal differentiation, with distinct functions in the cytoplasm, at the plasma membrane and in the nucleus. Here we report that the transcriptional corepressor TRIM28 is the major binding partner for nuclear WTX. The WTX-TRIM28 interaction supports chromatin binding by TRIM28, enhancing transcriptional silencing of some TRIM28 target sequences. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL14759
5 Samples
Download data: XLS
Series
Accession:
GSE60418
ID:
200060418
4.

Differential contribution of p300 and CBP to regulatory elements in mESCs

(Submitter supplied) In this study we analyze the individual contribution of p300 and CBP to the H3K27ac landscape, chromatin accessibility, and transcription in mESC. This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL19057
31 Samples
Download data: BW
Series
Accession:
GSE138925
ID:
200138925
5.

Differential contribution of p300 and CBP to regulatory elements in mESCs [RNA-seq]

(Submitter supplied) In this study we analyze the individual contribution of p300 and CBP to the H3K27ac landscape, chromatin accessibility, and transcription in mESC.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
8 Samples
Download data: BW
Series
Accession:
GSE138924
ID:
200138924
6.

Differential contribution of p300 and CBP to regulatory elements in mESCs [ATAC-seq]

(Submitter supplied) In this study we analyze the individual contribution of p300 and CBP to the H3K27ac landscape, chromatin accessibility, and transcription in mESC.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
8 Samples
Download data: BW
Series
Accession:
GSE138923
ID:
200138923
7.

Differential contribution of p300 and CBP to regulatory elements in mESCs [ChIP-seq]

(Submitter supplied) In this study we analyze the individual contribution of p300 and CBP to the H3K27ac landscape, chromatin accessibility, and transcription in mESC.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
15 Samples
Download data: BW
Series
Accession:
GSE138922
ID:
200138922
8.

RNA-seq analysis to identify the genes regulated by p53-SET interplay

(Submitter supplied) To identify the genes regulated by SET in a p53-dependent manner, the endogenous SET was depleted by siRNA in control or p53 knockout U2OS cells. Total RNA from each sample was extracted and the whole profile of gene expression was analyzed by RNA-seq analysis.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
10 Samples
Download data: CSV
9.

microRNA expression profiling among WTX low human colorectal cancer tissues and matched adjacent WTX high normal colorectal mucosa

(Submitter supplied) Comparing to matched normal mucosa, WTX was lost in most of human colorectal cancers (Zhang et al., 2016). We analyzed the microRNA expression profiling among WTX low human colorectal cancer tissues and matched adjacent WTX high normal colorectal mucosa. The aimed to identify the unique signature of miRNAs which related to WTX loss in human colorectal cancers.
Organism:
Rattus norvegicus; Macacine gammaherpesvirus 4; Human gammaherpesvirus 8; Betapolyomavirus macacae; Homo sapiens; Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL16414
10 Samples
Download data: GPR, TXT
Series
Accession:
GSE94881
ID:
200094881
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Supplemental Content

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