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Links from GEO DataSets

Items: 6

1.
Full record GDS4819

Inhibitor of NEDD8-activating enzyme MLN4924 effect on melanoma cell line

Analysis of A375 melanoma cells treated with small molecule MLN4924 for up to 24 hrs. MLN4924 selectively inhibits Nedd8-activating enzyme resulting in inactivation of the entire family of Cullin-RING ubiquitin ligases. Results provide insight into the molecular basis of MLN4924-induced cell death.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 5 time sets
Platform:
GPL570
Series:
GSE30531
30 Samples
Download data: CEL
DataSet
Accession:
GDS4819
ID:
4819

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

2.

Expression data of A375 melanoma cells after DMSO or MLN4924 treatment from 1 hour to 24 hour

(Submitter supplied) Microarrays were used to determine the change in gene expression of genes involved in the CDT1/NAE pathway
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4819
Platform:
GPL570
30 Samples
Download data: CEL
Series
Accession:
GSE30531
ID:
200030531

PubMed Full text in PMC Similar studies Analyze with GEO2R

3.

MLN4924 in chronic lymphocytic leukemia

(Submitter supplied) CLL cells obtained from patients with CLL were treated with MLN4924 to determine whether NFkB transcription targets were affected by the drug.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
22 Samples
Download data: TXT
Series
Accession:
GSE44864
ID:
200044864

PubMed Full text in PMC Similar studies Analyze with GEO2R

4.

Gene expression profiles of myeloma cells treated with NAE inhibitor

(Submitter supplied) The transcriptional profile of the human multiple myeloma (MM) cell line MM.1S treated with MLN4924 vs control MM.1S cells was characterized by oligonucleotide microarray analysis, using the human U133 plus 2.0 Affymetrix GeneChip, according to previously described protocols for total RNA extraction and purification; cDNA synthesis; in vitro transcription reaction for production of biotin-labeled cRNA; hybridization of cRNA with U133plus2.0 Affymetrix gene chips; and scanning of image output files. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
4 Samples
Download data: CEL
Series
Accession:
GSE33577
ID:
200033577

PubMed Full text in PMC Similar studies Analyze with GEO2R

5.

DNA damage Signaling Pathway PCR Array to profile the expression of human genes regulating in the DNA damage response (DDR) network

(Submitter supplied) Human DNA Damage Signaling Pathway RT2 Profiler Array Kit (Qiagen, Valencia, CA) was used to profile the expression of key genes involved in the DDR network as per the manufacturer’s instructions.
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL21406
4 Samples
Download data: TXT
Series
Accession:
GSE77560
ID:
200077560

PubMed Full text in PMC Similar studies Analyze with GEO2R

6.

Liver Cullin 3 knockout transcriptomics

(Submitter supplied) To investigate the liver transcriptomics of WT and liver Cullin 3 KO mice on chow diect (CD) and Westrn diet (WD)
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
14 Samples
Download data: XLS
Series
Accession:
GSE230518
ID:
200230518

PubMed Full text in PMC Similar studies

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