Similar studies for GEO DataSets (Select 4885) - GEO DataSets

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Items: 20

Select item 48851.

Kruppel-like zinc finger protein ZNF217 overexpression effect on breast cancer cell line

Analysis of MDA-MB-231 cells overexpressing ZNF217. ZNF217 is a Kruppel-like zinc finger protein that localizes to the nucleus. Results provide insight into the role of ZNF217 in the progression of breast cancer.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 protocol sets

Platform:: GPL570
Series:: GSE35511
4 Samples

Download data: CEL

DataSet

Accession:: GDS4885

ID:: 4885

Select item 2000355112.

Gene-expression profiling of ZNF217-overexpressing MDA-MB-231 cells

(Submitter supplied) To obtain an overview of the cellular functions regulated by ZNF217 signaling in breast-cancer cell lines, we performed global gene-expression profiling on MDA-MB-231-pcDNA6 and MDA-MB-231-ZNF217 cells

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4885
Platform:: GPL570
4 Samples

Download data: CEL

Series

Accession:: GSE35511

ID:: 200035511

Select item 2000470113.

Human breast cancer SKBr-3 cells: trastuzumab-resistant vs. parental

(Submitter supplied) Human breast cancer SKBr-3 cells selected with trastuzumab for 6 month compared with parental SKBr-3 cells; Goal was to screen for microRNAs involved in development of trastuzumab resistance.

Organism:: Mus musculus; Murid betaherpesvirus 1; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; human gammaherpesvirus 4; Mus musculus cytomegalovirus 2; Betapolyomavirus macacae; Rattus norvegicus; Human alphaherpesvirus 2; Murid gammaherpesvirus 4; Betapolyomavirus hominis; Merkel cell polyomavirus

Type:: Non-coding RNA profiling by array

Platform:: GPL11434
6 Samples

Download data: GPR

Series

Accession:: GSE47011

ID:: 200047011

Select item 2000548004.

lncRNA-Activated by TBGF-β-induced transcriptional changes and binding targets in hepatocellular carcinoma cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array; Other

Platforms:: GPL15314 GPL16951 GPL11154
14 Samples

Download data: GPR, TXT

Series

Accession:: GSE54800

ID:: 200054800

Select item 2000547995.

Genome-wide identification of transcripts associated with lncRNA-ATB by RIP-seq

(Submitter supplied) The role of TGF-β-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination is well established, but the involvement of lncRNAs in TGF-β signaling is still unknown. In this study, we observed that the lncRNA-Activated by TGF-β (lncRNA-ATB) was upregulated in hepatocellular carcinoma (HCC) metastases and associated with poor prognosis. lncRNA-ATB upregulated ZEB1 and ZEB2 by competitively binding the miR-200 family and then induced EMT and invasion. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL11154
2 Samples

Download data: TXT

Series

Accession:: GSE54799

ID:: 200054799

Select item 2000547986.

Expression profiling of SMMC-7721 cells: stably express lncRNA-ATB vs pcDNA3.1

(Submitter supplied) lncRNA-ATB induced transcriptional changes in SMMC-7721

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16951
6 Samples

Download data: GPR

Series

Accession:: GSE54798

ID:: 200054798

Select item 2000547977.

Long non-coding RNAs and mRNAs regulated by TGF-β

(Submitter supplied) The role of TGF-β-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination is well established, but the involvement of lncRNAs in TGF-β signaling is still unknown. In this study, we observed that the lncRNA-Activated by TGF-β (lncRNA-ATB) was upregulated in hepatocellular carcinoma (HCC) metastases and associated with poor prognosis. lncRNA-ATB promotes the invasion-metastasis cascade, which suggest that lncRNA-ATB, a mediator of TGF-β signaling, could predispose HCC patients to metastases and may serve as a potential target for anti-metastatic therapies.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array; Expression profiling by array

Platform:: GPL15314
6 Samples

Download data: TXT

Series

Accession:: GSE54797

ID:: 200054797

Select item 2000203188.

YWHAZ is an Invasion and Metastasis promoting genes of Lung cancer

(Submitter supplied) Metastasis is a major cause leading to mortality for lung cancer patients. We identified YWHAZ as a potential metastasis-promoting candidate and found that overexpression of YWHAZ promotes lung cancer cell proliferation, anchorage-independent growth, migration, and invasion in vitro, as well as tumorigenesis and metastasis in vivo. It not only increases cell protrusions and branchings but also induces epithelial-mesenchymal transition. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE20318

ID:: 200020318

Select item 2000247279.

The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression

(Submitter supplied) The transcription factor ZNF217 is a candidate oncogene in the amplicon on chromosome 20q13 that occurs in 20-30% of primary human breast cancers and that correlates with poor prognosis. We show Znf217 overexpression drives aberrant differentiation and signaling events, promotes increased self-renewal capacity, mesenchymal marker expression, motility and metastasis, and represses an adult tissue stem cell gene signature downregulated in cancers. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11062
8 Samples

Download data: TXT

Series

Accession:: GSE24727

ID:: 200024727

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002365510.

Expression data from Control and Six1 expressing MCF7 cells

(Submitter supplied) Inappropriate activation of developmental pathways is a well-recognized tumor-promoting mechanism. Here we show that overexpression of the homeoprotein Six1, normally a developmentally restricted transcriptional regulator, increases Transforming Growth Factor-beta (TGF-beta) signaling in mammary carcinoma cells and induces an epithelial to mesenchymal transition (EMT) that is in part dependent on its ability to increase TGF-beta signaling. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL3921
20 Samples

Download data: CEL

Series

Accession:: GSE23655

ID:: 200023655

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006355811.

Mesenchymal cancer cell-stromal crosstalk promotes niche activation, epithelial reversion and metastatic colonization

(Submitter supplied) The experiment was design to address the intrinsic differences between metastatic cancer stem cells in the primary tumour and during metastatic colonization in the mouse mammary gland tumour model MMTV-pyMT.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
3 Samples

Download data: TXT

Series

Accession:: GSE63558

ID:: 200063558

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20016745712.

RNA-seq of NIC+,CdGAPwt/wt and NIC+,CdGAPfx/fx tumors

(Submitter supplied) CdGAP/ARHGAP31 is a molecular target of TGFb-mediated EMT and required for Her2-positive breast cancer growth and metastasis Metastasis is the leading cause of death in breast cancer patients. The epithelial-to-mesenchymal transition (EMT) has a crucial role in metastasis and is highly critical for tumor cell dissemination. CdGAP/ARHGAP31 is highly expressed in breast cancer tissues and is associated with poor clinical outcome in breast cancer patients. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: TXT, XLSX

Series

Accession:: GSE167457

ID:: 200167457

PubMed Similar studies SRA Run Selector

Select item 20009959613.

SIRT7 Antagonizes TGF-β Signaling and Inhibits Breast Cancer Metastasis

(Submitter supplied) Protein deacetylase SIRT7 is significantly downregulated in lung metastases of human patient and mouse tissues, and predicted metastasis-free survival. To explore the roles of SIRT7 in breast cancer, we analysed the gene expressions in breast cancer BT549 cells with SIRT7 knockdown or not.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
6 Samples

Download data: XLSX

Series

Accession:: GSE99596

ID:: 200099596

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20019254814.

Transcriptome analysis of MCF10A-M2 cells upon the depletion of OVOL1 or OVOL2

(Submitter supplied) OVOL1 protein was shown to be downregulated in breast cancer patient samples and was inversely correlated with the epithelial-to-mesenchymal transition (EMT) signature. To better dissect the downstream target genes and elucidate the signaling pathways altered by OVOL1, we deplete OVOL1 by the specific siRNA in MCF10A-M2 cells. To set as a control, OVOL2 was knockdown by the specific siRNA in the same cell line. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28038
9 Samples

Download data: TXT

Series

Accession:: GSE192548

ID:: 200192548

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005206615.

14-3-3ζ promotes TGF-β-induced bone metastasis program in 231 cells

(Submitter supplied) To explore the regulatory role of 14-3-3ζ in TGF-β induced bone metastasis program in 231 cells, we generated MDA-MB-231 human breast cancer cell sublines with 14-3-3ζ shRNA knockdown (231.ZKD-4 and 231.ZKD-5) and scrambled shRNA (231.Scr) We performed cDNA microarray analysis on these cells treated with vehicle or TGF-β (5ng/ml, 2 hours) respectively in vitro

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10904
12 Samples

Download data: IDAT, TXT

Series

Accession:: GSE52066

ID:: 200052066

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005203216.

14-3-3ζ overexpression-induced gene signature in MCF-10A cells

(Submitter supplied) To study the function of 14-3-3ζ, we established MCF-10A human mammary epithelial cells transduced with 14-3-3ζ (10A.ζ) and vector (10A.Vec) We performed gene expression profiling on 10A.ζ cells and 10A.Vec cells, and normalized to profiling of MCF-10A parental cells

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
3 Samples

Download data: CEL, TXT

Series

Accession:: GSE52032

ID:: 200052032

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001402017.

Metastases of breast cancer

(Submitter supplied) Comparisons among breast cancer metastases at different organs revealed distinct microenvironments as characterized by cytokine content. Such microenvironment distinction might be important to dictate how the cancer cells adapt to survival before they successfully colonize. This SuperSeries is composed of the SubSeries listed below.