GEO DataSets

Analysis of AsPC1 pancreatic adenocarcinoma (PDAC) cells treated with IGC-001 up to 24 hours. IGC-001 binds to CREB-binding protein to disrupt its interaction with β-catenin. Results compared to β-catenin depletion (GDS5324) and provide insight into the therapeutic potential of IGC-001 in PDAC.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 2 time sets

Platform:

GPL570

Series:

GSE57728

12 Samples

Download data: CEL

(Submitter supplied) The CREB binding protein inhibitor ICG-001 suppresses pancreatic cancer growth We used microarrays to detail global gene expression changes in the pancreatic cancer cell line AsPC1 following treatment with ICG-001 or siRNA-mediated knockdown of CTNNB1 (beta-catenin)

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS5323 GDS5324

Platform:

GPL570

16 Samples

Download data: CEL

Analysis of AsPc1 pancreatic adenocarcinoma cells depleted for beta-catenin. Dysregulation of Wnt/β-catenin signaling is implicated in the pathogenesis of cancers. Results compared to those from AsPC1 cells treated with the CREB-binding protein inhibitor ICG-001 (GDS5323).

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL570

Series:

GSE57728

4 Samples

Download data: CEL

(Submitter supplied) Head and neck squamous cell carcinoma (HNSCC) presents primarily as oral squamous cell carcinoma (OSCC), an aggressive malignancy characterized by heterogeneity, locoregional metastases and resistance to existing treatments. Although a number of molecular alterations associated with OSCC have been identified, they have had limited impact on clinical management. A frequent feature of OSCC is the inappropriate activation of nuclear β-catenin. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

18 Samples

Download data: CEL

(Submitter supplied) Pancreatic ductal adenocarcinoma (PDAC) remains a major unsolved health problem. Most drugs that pass preclinical tests fail in these patients, emphasizing the need of appropriate preclinical models to test novel anticancer strategies. We developed four orthotopic mouse models employing primary human PDAC cells expressing Firefly and Gaussia luciferases, enabling bioluminescence monitoring of tumor growth and metastasis formation. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL16694

8 Samples

Download data: TXT

(Submitter supplied) We examined the effects of ICG-001 on gene expression in Mel202 uveal melanoma (UM) cells. ICG-001 exerted strong antiproliferative activity against UM cells, leading to cell cycle arrest, apoptosis, and inhibition of migration. Global gene expression profiling revealed strong suppression of genes associated with cell cycle proliferation, DNA replication, and G1/S transition. Gene set enrichment analysis revealed that ICG-001 suppressed Wnt, mTOR, and MAPK signaling. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

14 Samples

Download data: TXT

(Submitter supplied) Pancreatic ductal adenocarcinoma (PDAC) is a nearly uniformly lethal malignancy, with most patients facing an adverse clinical outcome. Given the pivotal role of aberrant Notch signaling in the initiation and progression of PDAC, we investigated the effect of MRK-003, a potent and selective γ-secretase inhibitor, in preclinical PDAC models. We used a panel of human PDAC cell lines, as well as patient-derived PDAC xenografts, to determine whether pharmacological targeting of the Notch pathway could inhibit pancreatic tumor growth and potentiate gemcitabine sensitivity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4342

Platform:

GPL570

18 Samples

Download data: CEL

Analysis of 9 individual patient-derived, pancreatic ductal adenocarcinoma (PDAC) xenografts treated with GSI MRK-003. MRK-003 monotherapy significantly reduced tumor volume in 5 of 9 xenografts. Results provide insight into the molecular basis of MRK-003-mediated attenuation of PDAC.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 9 cell line, 2 other sets

Platform:

GPL570

Series:

GSE37645

18 Samples

Download data: CEL

(Submitter supplied) The major obstacle to human immunodeficiency type 1 (HIV-1) eradication is a reservoir of latently-infected cells that persists despite long-term antiretroviral therapy (ART) and is maintained through cellular proliferation. Long-lived memory CD4+ T-cells with high self-renewal capacity such as central memory T-cells (CM) and T memory stem cells (SCM) are major contributors to the viral reservoir in HIV-infected individuals on ART. more...

Organism:

Macaca mulatta

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23804

47 Samples

Download data: TXT

(Submitter supplied) Analyses of mirna transcript levels following exposure to the drug triptolide in vitro and prodrug minnelide in xenograft pancreatic tumor mouse models.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL8179

42 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6102

41 Samples

Download data: TXT

(Submitter supplied) We evaluated the change in expression of genes after treatment of stellate cells with retinoic acid to understand how the stellate cells can de-differentiate and effect their physiological behaviour in pathological conditions. We then tested the changes in the gene expression in 2D and 3D culture conditions for pancreatic stellate cells and in a pancreatic cancer model. Keywords: gene expression change, time course

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6102

30 Samples

Download data: TXT

(Submitter supplied) We evaluated the change in expression of genes after treatment of stellate cells with retinoic acid to understand how the stellate cells can de-differentiate and effect their physiological behaviour in pathological conditions. We then tested the changes in the gene expression in 2D and 3D culture conditions for pancreatic stellate cells and in a pancreatic cancer model. Keywords: gene expression change, dose response, matrix conditions

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6102

11 Samples

Download data: TXT

(Submitter supplied) Inhibition of histone acetyltransferase has been widely used to be effectively treat cancers in many studies. However, it’s not clear how the downstream signaling responds to the inhibitor in pancreatic cancer. Here we performed Hi-C experiments and RNA-seq to canonical and patient-derived pancreatic cancer cells with the treatment of small molecule inhibitor ICG-001 which has dual function to block both WNT signaling and histone acetyltransferase. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21290

24 Samples

Download data: TXT

(Submitter supplied) Inhibition of histone acetyltransferase has been widely used to be effectively treat cancers in many studies. However, it’s not clear how the downstream signaling responds to the inhibitor in pancreatic cancer. Here we performed Hi-C experiments to canonical and patient-derived pancreatic cancer cells with the treatment of small molecule inhibitor ICG-001 which has dual function to block both WNT signaling and histone acetyltransferase. more...

Organism:

Homo sapiens

Type:

Other

Platform:

GPL21290

8 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing; Expression profiling by array

Platforms:

GPL13497 GPL16791

12 Samples

Download data: TXT

(Submitter supplied) Purpose: To determine the differentially expressed genes in cancer associated fibroblasts upon ablation of the glutamatergic synapse protein NetrinG1. Methods: Cancer associated fibroblast mRNA profiles were generated from Control and NetrinG1 KO fibroblast lines, with controls done in duplicate and KOs in triplicate. Results: Comparing the mRNA profiles of CON and NetrinG1 KO CAFs, we observed a reversion of many pro-tumor genes and associated pathways upon ablation of NetrinG1 in CAFs. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

8 Samples

Download data: TXT

(Submitter supplied) Cancer associated fibroblast mRNA profiles were generated from Control and NetrinG1 KO fibroblast lines, with controls done in duplicate and KOs in triplicate. Comparing the mRNA profiles of CON and NetrinG1 KO CAFs, we observed a reversion of many pro-tumor genes and associated pathways upon ablation of NetrinG1 in CAFs.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13497

4 Samples

Download data: TXT