GEO DataSets

Analysis of amniotic membrane-expanded limbal epithelium (AMLE) and corneal epithelium (CE). AMLE transplantation in place of donor CE significantly improves outcome in severe limbal stem cell deficiency cases. Results provide insight into molecular processes which characterize AMLE and CE tissues.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 growth protocol, 2 tissue sets

Platform:

GPL6244

Series:

GSE56421

6 Samples

Download data: CEL

(Submitter supplied) Transplantation of amniotic membrane-expanded limbal epithelium (AMLE) in place of donor tissue grafts results in significantly improved outcomes for patients suffering from severe limbal stem cell deficiency; however the reasons for such superior results are unclear. The purpose of this study was to identify transcriptional gene profiles specific to AMLE and donor central corneal epithelium (CE), which may contribute to the divergent clinical outcomes observed following transplant. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5366

Platform:

GPL6244

9 Samples

Download data: CEL

(Submitter supplied) Limbal and central regoins of the rat cornea epithelium were used to constract 2 SAGE libraries, in order to identify candidate genes to distinguish stem cell from differentiated central cornea epithelium cells. Keywords: gene expression SAGE-based, count

Organism:

Rattus norvegicus

Type:

Expression profiling by SAGE

Platform:

GPL23

2 Samples

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(Submitter supplied) PAX6-related Aniridia is a sight-threatening disease due to progression of secondary glaucoma and aniridia associated keratopathy (AAK). Changes or loss of limbal epithelial progenitors causes the epithelial surfaces defects. We analyzed how PAX6 contribute to this with a two-step approach. 1) mRNA Sequencing of limbal epithelial cells isolated from controls and aniridia patients. 2) confirming the bioinformatical and literature-based result list on a siRNA based primary aniridia cell model (PAX6- knockdown). more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

4 Samples

Download data: BW

(Submitter supplied) We first reported that WNT16 has the advanced effect on the proliferation and stemness maintenance of human limbal epithelial stem cells. To investigte the potential mechanism of WNT16 regulation, RNA-seq was used to analyze the differential expressed genes and relative cellular pathways between WNT16-treated and wild type human limbal epithelial stem cells.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24676

6 Samples

Download data: TXT