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Links from GEO DataSets

Items: 11

1.
Full record GDS854

Transforming growth factor beta effect on acute myelogenous leukemia cells

Analysis of M091 acute myelogenous leukemia cells after treatment with 200 pM transforming growth factor beta (TGFbeta) for 2 and 4 hours. Part of a study comparing M091 to hematopoietic stem cells. Reveals cytostatic role of TGFbeta in hematopoiesis and identifies p57 as a possible tumor suppressor
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 3 time sets
Platform:
GPL8300
Series:
GSE1805
8 Samples
Download data
DataSet
Accession:
GDS854
ID:
854

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

2.

TGFbeta targets in M091 cell line

(Submitter supplied) Treatment of Leukemia derived M091 cell line with TGF beta Keywords: other
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS854
Platform:
GPL8300
8 Samples
Download data
Series
Accession:
GSE1805
ID:
200001805

PubMed Full text in PMC Similar studies Analyze with GEO2R

3.

CBCD34-TGFbeta targets

(Submitter supplied) TGFbeta regulated genes in human umbilical cord blood CD34+ cells Keywords: other
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS855
Platform:
GPL96
11 Samples
Download data
Series
Accession:
GSE1802
ID:
200001802

PubMed Full text in PMC Similar studies Analyze with GEO2R

4.
Full record GDS855

Transforming growth factor beta effect on CD34+ hematopoietic stem cells

Analysis of CB-CD34 CD34+ hematopoietic stem cells after treatment with 200 pM TGFbeta for 2 and 4 hours. Part of a study comparing CB-CD34 cells to acute myelogenous leukemia cells. Reveals cytostatic role of TGFbeta in hematopoiesis and identifies p57 as a possible tumor suppressor.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 3 time sets
Platform:
GPL96
Series:
GSE1802
11 Samples
Download data
DataSet
Accession:
GDS855
ID:
855

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

5.

A network including TGFβ/Smad4, Gata2 and p57 regulates proliferation of mouse hematopoietic stem/progenitor cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL9250 GPL7202
7 Samples
Download data: TXT
Series
Accession:
GSE73642
ID:
200073642

PubMed Similar studies Analyze with GEO2R

6.

A network including TGFβ/Smad4, Gata2 and p57 regulates proliferation of mouse hematopoietic stem/progenitor cells [ChIP-seq]

(Submitter supplied) Transforming growth factor-β (TGFβ) is a potent inhibitor of hematopoietic stem cell (HSC) proliferation. However, the precise mechanism for this effect is unknown. Here, we have identified the transcription factor Gata2, previously described as an important regulator of HSC function, as an early and direct target gene for TGFβ-induced Smad signaling in hematopoietic stem and progenitor cells (HSPCs). more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9250
1 Sample
Download data: TXT
Series
Accession:
GSE73641
ID:
200073641

PubMed Similar studies SRA Run Selector

7.

A network including TGFβ/Smad4, Gata2 and p57 regulates proliferation of mouse hematopoietic stem/progenitor cells [expression]

(Submitter supplied) Transforming growth factor-β (TGFβ) is a potent inhibitor of hematopoietic stem cell (HSC) proliferation. However, the precise mechanism for this effect is unknown. Here, we have identified the transcription factor Gata2, previously described as an important regulator of HSC function, as an early and direct target gene for TGFβ-induced Smad signaling in hematopoietic stem and progenitor cells (HSPCs). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
6 Samples
Download data: TXT
Series
Accession:
GSE73567
ID:
200073567

PubMed Similar studies Analyze with GEO2R

8.

Identification of hypoxia, HIF1 and HIF2 target genes in human CB CD34+ cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
5 Samples
Download data
Series
Accession:
GSE54663
ID:
200054663

PubMed Full text in PMC Similar studies Analyze with GEO2R

9.

Identification of HIF1 and HIF2 target genes in human CB CD34+ cells

(Submitter supplied) Although it has been shown that HIF1 and 2 fulfill essential roles within the hematopoietic system and in the regulation of HSC fate, little is currently known about the specific mechanisms that are involved. We identified transcriptome changes induced by hypoxia, constitutively active HIF1(P402/564) and HIF2(P405/531) in human cord blood CD34+ cells. Thus, we were able to identify common hypoxia-HIF1-HIF2 gene signatures, but we also identified specific target genes that were exclusively regulated by HIF1, HIF2 or hypoxia.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
3 Samples
Download data: TXT
Series
Accession:
GSE54662
ID:
200054662

PubMed Full text in PMC Similar studies Analyze with GEO2R

10.

Identification of hypoxia target genes in human CB CD34+ cells

(Submitter supplied) Although it has been shown that HIF1 and 2 fulfill essential roles within the hematopoietic system and in the regulation of HSC fate, little is currently known about the specific mechanisms that are involved. We identified transcriptome changes induced by hypoxia, constitutively active HIF1(P402/564) and HIF2(P405/531) in human cord blood CD34+ cells. Thus, we were able to identify common hypoxia-HIF1-HIF2 gene signatures, but we also identified specific target genes that were exclusively regulated by HIF1, HIF2 or hypoxia.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
2 Samples
Download data: TXT
Series
Accession:
GSE54661
ID:
200054661

PubMed Full text in PMC Similar studies Analyze with GEO2R

11.

TGF-beta responsive gene in primary osteoblast.

(Submitter supplied) Gene expression profiling of a total of 3,774 genes in primary osteoblastic cells treated with TGF-beta1 Keywords: cytokine response
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL125
2 Samples
Download data: JPG, TIFF, TXT, XLS
Series
Accession:
GSE11702
ID:
200011702

PubMed Full text in PMC Similar studies Analyze with GEO2R

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