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Full record GDS3774

microRNA-124 guide strand segmentation effect on HCT-116 Dicer hypomorph cells

Analysis of HCT-116 dicer- cells transfected with miR-124 duplex containing a segmented guide strand. Following miRNA guide strand segmentation, seed-based (positions 2 through 8 at the 5' end of the guide strand) activity persisted. Results illustrate a structural flexibility in miRNA duplexes.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 protocol sets
Platform:
GPL10379
Series:
GSE25224
4 Samples
Download data: CEL

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