Loss of a histone deacetylase dramatically alters the genomic distribution of Spo11p-catalyzed DNA breaks in yeast - - GEO DataSets

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Loss of a histone deacetylase dramatically alters the genomic distribution of Spo11p-catalyzed DNA breaks in yeast

(Submitter supplied) In eukaryotes, meiotic recombination events are distributed non-randomly in the genome with certain regions having high levels of recombination (hotspots) and others having low levels (coldspots). Species with similar DNA sequences (for example, chimpanzees and humans) can have strikingly different patterns of hotspots and coldspots. Below, using a microarray analysis that allows us to measure the frequency of the meiosis-specific double-strand DNA breaks (DSBs) of all 6000 yeast genes, we show that mutation of a single gene (SIR2), which encodes a histone deacetylase, significantly changes DSB frequencies of 12% of yeast genes, elevating DSBs of 5% and reducing DSBs of 7%. more...

Organism:: Saccharomyces cerevisiae

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL4414
24 Samples

Download data: GPR

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Accession:: GSE6245

ID:: 200006245

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