CD38 modulates CXCR4 signals in chronic lymphocytic leukemia cells: potential therapeutic implications - - GEO DataSets

Summary

Format

Summary
Summary (text)
Unique Identifier List

Send to:

Choose Destination

File
Clipboard
Collections

Links from PMC

CD38 modulates CXCR4 signals in chronic lymphocytic leukemia cells: potential therapeutic implications

(Submitter supplied) Recent data indicate that CD38, a cell surface enzyme and receptor, is part of the complex network of signals underlying the development, maintenance and progression of chronic lymphocytic leukemia (CLL). Here we show that CD38 signals directly facilitate short- (ERK1/2 phosphorylation) and long-term (chemotaxis) effects induced by CXCL12 exposure. Use of i) a specific enzyme inhibitor, ii) an agonistic anti-CD38 monoclonal antibody (mAb) and iii) microarray studies led to the conclusion that the receptor-like functions of CD38 are responsible for the observed effects. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL1708
30 Samples

Download data: TXT

Series

Accession:: GSE14063

ID:: 200014063

PubMed Full text in PMC Similar studies Analyze with GEO2R

Supplemental Content

GEO DataSets

Functional Genomics Studies

Result Filters

Send to:

Links from PMC

Supplemental Content

Related information

Important Links

Recent activity