GEO DataSets

(Submitter supplied) This dataset comprises expression profiles from 3 thymic lymphomas from Ikaros deficient mice (IkL/L model, see Dumortier et al, Mol. Cell. Biol. 26, 209-220, 2006 for a description of the tumor model) and 3 thymic lymphomas from IkL/L mice that harbor a mutation of the Notch1 gene (deletion of floxed sequences comprising the promoter and exon 1 with the CD4-Cre transgene). The results from this experimpent is that the expression of Notch target genes was unexpectedly not altered in the tumors with the Notch1 deletion. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4174

Platform:

GPL1261

6 Samples

Download data: CEL

Analysis of thymic tumors from Ikaros-deficient (IkL/L) mice with a Notch promoter/exon1 deletion. The deletion of Notch1 promoter results in oncogenic activation of Notch1 and significantly accelerates leukemogenesis. Results provide insight into role of Notch activation in pathogenesis of T-ALL.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 age, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE23972

6 Samples

Download data: CEL