GEO DataSet Links for PMC (Select 3201200) - GEO DataSets

Select item 2000260851.

BCL6 is required for the initiation and maintenance of chronic myeloid leukemia

(Submitter supplied) We identified the BCL6 protooncogene as a critical downstream effector of FoxO3A in self-renewal signaling of CML-initiating cells. BCL6 represses Arf and p53 in CML cells and is required for leukemia stem cell maintenance, colony formation and initiation of leukemia in transplant recipients. Importantly, peptide inhibition of BCL6 in human CML cells compromises colony formation and leukemia-initiation in xenotransplanted mouse recipients. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL10999
2 Samples

Download data: BED, TXT, WIG

Series

Accession:: GSE26085

ID:: 200026085

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000248142.

Role and function of STAT5 in BCR-ABL1 driven pre-B cells

(Submitter supplied) In order to investigate the function of STAT5 in ALL, we isolated bone marrow cells from STAT5 fl/fl mice and transformed them with BCR-ABL1. In a second transduction the BCR-ABL1 driven pre-B cells were transformed either with CRE-GFP or empty vector control (GFP) and subjected to gene expression analysis.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
6 Samples

Download data: CEL

Series

Accession:: GSE24814

ID:: 200024814

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000248133.

Gene expression data of BCR-ABL1 transformed myeloid cells from BCL6 wild-type and BCL6 knockout mice treated with and without Imatinib and RI-BPI

(Submitter supplied) To identify differences in the gene regulation between BCL6+/+ and BCL6-/- CML cells a gene expression analysis has been performed. We investigated the gene expression pattern in BCL6+/+ cells in the presence or absence of Imatinib and a combination of Imatinib and RI-BPI (a novel retro-inverso BCL6 peptide inhibitor). In BCL6-/- CML cells, we investigated the gene expression pattern in the presence or absence of Imatinib. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
10 Samples

Download data: CEL

Series

Accession:: GSE24813

ID:: 200024813

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000244934.

Effect of Imatinib on chronic myelogenous leukemia

(Submitter supplied) The Philadelphia chromosome (Ph) encodes the oncogenic BCR-ABL1 tyrosine kinase, which is present in almost every patient with chronic myeloid leukemia. In this study, the tyrosine kinase inhibitor Imatinib was used for pharmacological inhibition of BCR-ABL1. Gene expression profiles of CML cell lines were analyzed in response to Imatinib treatment.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4177
Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE24493

ID:: 200024493

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000209875.

Gene expression data of BCR-ABL1 transformed B cell precursors from BCL6 wild-type and BCL6 knockout mice

(Submitter supplied) To elucidate the mechanism of BCL6-mediated pre-B cell survival signaling, we investigated the gene expression pattern in BCR-ABL1-transformed BCL6+/+ and BCL6-/- B cell precursors. Pharmacological inhibition of BCR-ABL1 was performed with the BCR-ABL1 kinase inhibitor STI571 (Imatinib).

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
12 Samples

Download data: CEL

Series

Accession:: GSE20987

ID:: 200020987

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 41776.

Imatinib treatment of chronic myeloid leukemia cell lines: KU-812, KCL-22 and JURL-MK1

Analysis of CML cell lines (KU-812, KCL-22, and JURL-MK1) treated with tyrosine kinase inhibitor imatinib. Imatinib inhibits oncogenic BCR-ABL1, a tyrosine kinase present in most CML patients. Results provide insight into molecular mechanisms underlying imatinib inhibition of CML.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 3 cell line sets

Platform:: GPL570
Series:: GSE24493
6 Samples

Download data: CEL

DataSet

Accession:: GDS4177

ID:: 4177

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

GEO DataSets

Functional Genomics Studies

Result Filters

Entry type

Organism

Study type

Author

Attribute name

Publication dates

Custom date range

Additional filters

Send to:

Links from PMC

Items: 6

Send to:

Supplemental Content

Find related data

Important Links

Recent activity