GEO DataSet Links for PMC (Select 3221734) - GEO DataSets

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Items: 2

Select item 2000222881.

Controlled ErbB receptor dimerization

(Submitter supplied) In order to better understand signaling events following receptor dimerization involving HER2, we have generated an experimental system in which ErbB dimerization can be controlled. We used gene expression microarrays to identify genes and pathways that are differentially activated by HER2 homodimers and HER2 containing heterodimers.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4361
Platform:: GPL6244
12 Samples

Download data: CEL, CHP

Series

Accession:: GSE22288

ID:: 200022288

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 43612.

AP1510, TGFα or heregulin ligand effect on MCF10 mammary epithelial cells expressing HER2-FKBP-HA chimeric receptors

Analysis of mammary epithelial MCF10A/HER2/FKBP/HA cells treated with AP1510 to induce the chimeric HER2-FKBP molecule to homodimerize, or with TGFα or heregulin to induce heterodimerization with EGFR or HER3. Results provide insight into signaling events following HER2 receptor dimerization.