GEO DataSet Links for PMC (Select 3625318) - GEO DataSets

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Items: 2

Select item 2000445371.

Transient treatment with epigenetic modifiers yields stable neuroblastoma stem cells resembling aggressive large-cell neuroblastomas

(Submitter supplied) Cancer stem cells (CSCs) are plastic in nature, a characteristic that hampers cancer therapeutics. Neuroblastoma (NB) is a pediatric tumor of neural crest origin, and half of the cases are highly aggressive. By treating NB cell lines (SKNAS, SKNBE(2)C, CHP134, SY5Y) with epigenetic modifiers for a short time followed by sphere-forming culture conditions, we have established stem cell-like NB cells that are phenotypically stable for over a year. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4618
Platform:: GPL570
6 Samples

Download data: CEL

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Accession:: GSE44537

ID:: 200044537

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 46182.

Neuroblastoma SKNAS induced cancer stem cells

Analysis of phenotypically stabilized stem cell-like NB cells (iCSCs) established from SKNAS NB cells by DNA methylation inhibitor 5-aza-2’-deoxycytidine (5AdC) treatment followed by sphere-forming culture conditions. Results provide insight into the molecular characteristics of SKNAS iCSCs.