GEO DataSet Links for PMC (Select 3784539) - GEO DataSets

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Items: 2

Select item 2000471791.

Effects of KAT2B and WDR5 depletion on hepatocyte gene expression

(Submitter supplied) During fasting, increases in circulating pancreatic glucagon maintain glucose balance by up-regulating hepatic gluconeogenesis. Triggering of the cAMP pathway stimulates the gluconeogenic program through the phosphorylation of CREB and via the de-phosphorylation of the CREB coactivator CRTC2. Hormonal and nutrient signals are also thought to modulate gluconeogenic genes by promoting epigenetic changes that facilitate assembly of the transcriptional machinery, although the nature of these modifications is unclear. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5673
Platform:: GPL6246
10 Samples

Download data: CEL, CHP

Series

Accession:: GSE47179

ID:: 200047179

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 56732.

Glucagon effect on hepatocytes deficient in lysine acetyltransferase 2B or WD repeat-containing protein 5

Analysis of C57BL6/J primary hepatocytes depleted of either lysine acetyltransferase 2B (KAT2B) or WD repeat-containing protein 5 (WDR5) via shRNA knockdown, then stimulated with glucagon for 90 minutes. Results provide insight into the roles of KAT2B and WDR5 in hepatic gluconeogenesis.