GEO DataSet Links for PMC (Select 3854113) - GEO DataSets

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Items: 2

Select item 2000515871.

Identification of IL-21-induced STAT3 dependent genes in human B cells

(Submitter supplied) IL-21 induces B cell activation, and differentiation into antibody-secreting plasmablasts in vitro. This process is abolished by loss-of function mutations in STAT3 We used microarrays to identify genes that are induced by IL-21 in a STAT3-dependent manner

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5242
Platform:: GPL6244
14 Samples

Download data: CEL

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Accession:: GSE51587

ID:: 200051587

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 52422.

Interleukin-21 effect on STAT3-deficient naïve B cells from autosomal dominant hyper IgE syndrome patients

Analysis of naïve B cells purified from peripheral blood of AD-HIES patients with STAT3 loss-of-function mutation and then cultured with CD40 ligand alone or together with interleukin-21. Results provide insight into IL-21R/STAT3 signaling induced genes underlying naïve B cell differentiation.