GEO DataSet Links for PMC (Select 3877755) - GEO DataSets

Select item 2000526231.

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation (RNA-seq)

(Submitter supplied) Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known to suppress tumor formation in several cancer types, we found that leukemia cells instead rely on Brg1 to support their oncogenic transcriptional program, which includes Myc as one of its key targets. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
21 Samples

Download data: TXT

Series

Accession:: GSE52623

ID:: 200052623

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000525952.

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation (4C-seq)

(Submitter supplied) Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known to suppress tumor formation in several cancer types, we found that leukemia cells instead rely on Brg1 to support their oncogenic transcriptional program, which includes Myc as one of its key targets. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL16417
6 Samples

Download data: WIG

Series

Accession:: GSE52595

ID:: 200052595

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000522793.

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other

Platforms:: GPL6246 GPL16417 GPL13112
42 Samples

Download data: CEL, TXT, WIG

Series

Accession:: GSE52279

ID:: 200052279

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000522774.

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation [ChIP-Seq]

(Submitter supplied) Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known to suppress tumor formation in several cancer types, we found that leukemia cells instead rely on Brg1 to support their oncogenic transcriptional program, which includes Myc as one of its key targets. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: WIG

Series

Accession:: GSE52277

ID:: 200052277

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000522315.

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation [array]

(Submitter supplied) Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known to suppress tumor formation in several cancer types, we found that leukemia cells instead rely on Brg1 to support their oncogenic transcriptional program, which includes Myc as one of its key targets. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
9 Samples

Download data: CEL

Series

Accession:: GSE52231

ID:: 200052231

PubMed Full text in PMC Similar studies Analyze with GEO2R

GEO DataSets

Functional Genomics Studies

Result Filters

Entry type

Organism

Study type

Author

Attribute name

Publication dates

Custom date range

Additional filters

Send to:

Links from PMC

Items: 5

Send to:

Supplemental Content

Find related data

Important Links

Recent activity