GEO DataSet Links for PMC (Select 4446704) - GEO DataSets

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Items: 2

Select item 2000571411.

Defining key signaling nodes and therapeutic biomarkers in NF1-mutant cancers

(Submitter supplied) The NF1 tumor suppressor encodes a RAS GTPase-Activating Protein (RasGAP). Accordingly, deregulated RAS signaling underlies the pathogenesis of NF1-mutant cancers. However, while various RAS effector pathways have been shown to function in these tumors, it is currently unclear which specific proteins within these broad signaling pathways represent optimal therapeutic targets. Here we identify mTORC1 as the key PI3K pathway component in NF1-mutant nervous system malignancies and conversely show that mTORC2 and AKT are dispensable. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5419
Platform:: GPL6246
8 Samples

Download data: CEL

Series

Accession:: GSE57141

ID:: 200057141

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 54192.

MEK inhibitor PD-0325901 and rapamycin combined treatment effect on malignant peripheral nerve sheath tumor model

Analysis of malignant peripheral nerve sheath tumors (MPNST) from NPcis animals (carrying Nf1 and p53 mutations) treated with rapamycin, MEK inhibitor PD-0325901, or the combination of rapamycin and PD-0325901. Results provide insight into the molecular mechanisms underlying MPNST pathogenesis.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 4 protocol sets

Platform:: GPL6246
Series:: GSE57141
8 Samples

Download data: CEL

DataSet

Accession:: GDS5419

ID:: 5419

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

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GEO DataSet Links for PMC (Select 4446704) (2)
GEO DataSets
Mus musculus growth factor receptor bound protein 10 (Grb10), transcript variant...
Mus musculus growth factor receptor bound protein 10 (Grb10), transcript variant 2, mRNA
gi|294979208|ref|NM_001177629.1|

Nucleotide
Mus musculus triggering receptor expressed on myeloid cells-like 1 (Treml1), tra...
Mus musculus triggering receptor expressed on myeloid cells-like 1 (Treml1), transcript variant 1, mRNA
gi|575402993|ref|NM_027763.2|

Nucleotide
Mus musculus adult male thymus cDNA, RIKEN full-length enriched library, clone:5...
Mus musculus adult male thymus cDNA, RIKEN full-length enriched library, clone:5830404F05 product:linker for activation of T cells, full insert sequence
gi|74137141|dbj|AK134003.1|

Nucleotide
Mus musculus urea transporter B mRNA, complete cds
Mus musculus urea transporter B mRNA, complete cds
gi|17864973|gb|AF448798.1|

Nucleotide

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