GEO DataSet Links for SRA (Select 2218159) - GEO DataSets

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Items: 2

Select item 3020579251.

Day 1 control

Organism:: Xenopus laevis

Source name:: RGC TRAP

Platform:: GPL17682
Series:: GSE77724

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Sample

Accession:: GSM2057925

ID:: 302057925

SRA Run Selector

Select item 2000777242.

Translational profiling of retinal ganglion cell optic nerve regeneration in Xenopus laevis

(Submitter supplied) Unlike adult mammals, adult frogs regrow and regenerate their optic nerve following a crush injury. Using Translational Ribosome Affinity Purification (TRAP), a method to isolate mRNAs actively undergoing translation in a target cell population, we have generated a transcriptional profile by RNA-Seq for retinal ganglion cells (RGC) during the period of recovery following an optic nerve injury. Based on bioinformatics analysis using the JGI 9.1 Xenopus laevis gene models, our results reveal a profound shift in the composition of actively translating mRNAs during the early stages of RGC regeneration: as factors involved in cell signaling are rapidly downregulated, and those involved in core metabolism are upregulated. more...