GEO DataSet Links for SRA (Select 7765496) - GEO DataSets

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Items: 2

Select item 3037436481.

RNA-seq_LPS-IFNG-1

Organism:: Homo sapiens

Source name:: CD14+ Monocytes

Platform:: GPL20301
Series:: GSE120945 GSE130567

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Sample

Accession:: GSM3743648

ID:: 303743648

SRA Run Selector

Select item 2001305672.

IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate M1-like macrophage polarization [RNA-seq II]

(Submitter supplied) Complete polarization of macrophages towards an M1-like proinflammatory and antimicrobial state requires combined action of IFN-γ and LPS. Synergistic activation of canonical inflammatory NF-κB target genes by IFN-γ and LPS is well appreciated, but less is known about whether IFN-γ negatively regulates components of the LPS response, and how this affects polarization. A combined transcriptomic and epigenomic approach revealed that IFN-γ selectively abrogates LPS-induced feedback and select metabolic pathways by suppressing TLR4-mediated activation of gene enhancers. more...