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Items: 1 to 20 of 53

1.

A Brucella ovis HWE histidine kinase is important for detergent resistance.

(Submitter supplied) Through a system-level analysis of non-essential two-component signal transduction systems (TCS) genes in Brucella ovis, we have discovered that deletion of an HWE histidine kinase, BOV_1602, leads to significant increase in resistance to SDS detergent and other anionic or zwitterionic detergents. To better understand this detergent resistance phenotype, we performed RNA-seq experiment using both WT and ∆BOV_1602 cultured on no stress (TASB) or TSAB supplemented with 0.004% SDS.
Organism:
Brucella ovis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL33317
12 Samples
Download data: XLSX
Series
Accession:
GSE262183
ID:
200262183
2.

A unique mode of cross regulation in a cell envelope stress signaling system

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Brucella ovis
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL33317
19 Samples
Download data
Series
Accession:
GSE229183
ID:
200229183
3.

A unique mode of cross regulation in a cell envelope stress signaling system [RNA-seq]

(Submitter supplied) A multi-layered structure known as the cell envelope separates the controlled interior of Gram-negative bacteria from a fluctuating physical and chemical environment. Transcription of genes that determine cell envelope structure and function is commonly controlled by a class of environmental regulators known as two-component signal transduction systems (TCS), which are comprised of 1) sensor histidine kinases and 2) response regulators. more...
Organism:
Brucella ovis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL33317
9 Samples
Download data: XLSX
Series
Accession:
GSE229181
ID:
200229181
4.

A unique mode of cross regulation in a cell envelope stress signaling system [ChIP-seq]

(Submitter supplied) A multi-layered structure known as the cell envelope separates the controlled interior of Gram-negative bacteria from a fluctuating physical and chemical environment. Transcription of genes that determine cell envelope structure and function is commonly controlled by a class of environmental regulators known as two-component signal transduction systems (TCS), which are comprised of 1) sensor histidine kinases and 2) response regulators. more...
Organism:
Brucella ovis
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL33317
10 Samples
Download data: CSV
Series
Accession:
GSE229120
ID:
200229120
5.

Transcriptional profiling of Brucella ovis strains cultivated in the presence of high (5%) and low (0.04%) CO2

(Submitter supplied) Wild-type Brucella ovis ATCC 25840 requires the addition of 5% CO2 to the atmosphere to grow on either nutrient agar plates or in liquid broth culture. The goal of this study was to measure the transcriptional response of two Brucella ovis strains under high (5%) and low (0.04%) CO2. The two strains assayed were 1) wild-type and 2) a spontaneous mutant that can be cultivated in standard atmospheric levels of CO2 (~0.04%). more...
Organism:
Brucella ovis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL26618
10 Samples
Download data: TXT
Series
Accession:
GSE130678
ID:
200130678
6.

Differential Expression of Iron Acquisition Genes by Brucella melitensis and Brucella canis During Macrophage Infection

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Brucella canis; Brucella ovis; Brucella melitensis; Brucella melitensis bv. 1 str. 16M
Type:
Expression profiling by array
Platforms:
GPL15024 GPL15023
16 Samples
Download data: CALLS, PAIR
Series
Accession:
GSE34504
ID:
200034504
7.

Differential Expression of Iron Acquisition Genes by Brucella melitensis and Brucella canis During Macrophage Infection (part 4)

(Submitter supplied) Brucella melitensis and Brucella canis differ by ~75 genes yet B. melitensis is highly virulent for humans while B. canis is considered rarely pathogenic. No identified bacterial factors or mechanisms account for this difference in virulence. To identify functional differences of these two bacteria, gene transcription was examined during infection of murine macrophages and compared to bacteria grown in broth. more...
Organism:
Brucella ovis; Brucella canis
Type:
Expression profiling by array
Platform:
GPL15024
4 Samples
Download data: CALLS, PAIR
Series
Accession:
GSE34503
ID:
200034503
8.

Differential Expression of Iron Acquisition Genes by Brucella melitensis and Brucella canis During Macrophage Infection (part 3)

(Submitter supplied) Brucella melitensis and Brucella canis differ by ~75 genes yet B. melitensis is highly virulent for humans while B. canis is considered rarely pathogenic. No identified bacterial factors or mechanisms account for this difference in virulence. To identify functional differences of these two bacteria, gene transcription was examined during infection of murine macrophages and compared to bacteria grown in broth. more...
Organism:
Brucella canis; Brucella ovis
Type:
Expression profiling by array
Platform:
GPL15024
4 Samples
Download data: CALLS, PAIR
Series
Accession:
GSE34501
ID:
200034501
9.

Differential Expression of Iron Acquisition Genes by Brucella melitensis and Brucella canis During Macrophage Infection (part 2)

(Submitter supplied) Brucella melitensis and Brucella canis differ by ~75 genes yet B. melitensis is highly virulent for humans while B. canis is considered rarely pathogenic. No identified bacterial factors or mechanisms account for this difference in virulence. To identify functional differences of these two bacteria, gene transcription was examined during infection of murine macrophages and compared to bacteria grown in broth. more...
Organism:
Brucella ovis; Brucella canis
Type:
Expression profiling by array
Platform:
GPL15024
4 Samples
Download data: CALLS, PAIR
Series
Accession:
GSE34498
ID:
200034498
10.

NextSeq 2000 (Brucella ovis)

Organism:
Brucella ovis
4 Series
31 Samples
Download data
Platform
Accession:
GPL33317
ID:
100033317
11.

Illumina HiSeq 4000 (Brucella ovis)

Organism:
Brucella ovis
1 Series
10 Samples
Download data
Platform
Accession:
GPL26618
ID:
100026618
12.

NimbleGen Brucella ovis array 2.9K v1.0

(Submitter supplied) Microarray design and experimentation were made by NimbleGen Systems, INC from catalogue design for B. ovis chromosomes I (NC_009505.1) and II (NC_009504.1) with 20 probes per gene (10 perfect matches and 10 mismatches). Each probe (60 mer) was replicated three times on chip (design includes random GC probes). Triplicate samples of each strain were mixed and one chip was made per strain.
Organism:
Brucella ovis
4 Series
12 Samples
Download data: NCD, NDF, NGD
Platform
Accession:
GPL15024
ID:
100015024
13.

∆BOV_1602_SDS replicate 3 [1602_453_S36]

Organism:
Brucella ovis
Source name:
B. ovis cells
Platform:
GPL33317
Series:
GSE262183
Download data
Sample
Accession:
GSM8159237
ID:
308159237
14.

∆BOV_1602_SDS replicate 2 [1602_452_S35]

Organism:
Brucella ovis
Source name:
B. ovis cells
Platform:
GPL33317
Series:
GSE262183
Download data
Sample
Accession:
GSM8159236
ID:
308159236
15.

∆BOV_1602_SDS replicate 1 [1602_451_S34]

Organism:
Brucella ovis
Source name:
B. ovis cells
Platform:
GPL33317
Series:
GSE262183
Download data
Sample
Accession:
GSM8159235
ID:
308159235
16.

WT_SDS replicate 3 [WT_450_S33]

Organism:
Brucella ovis
Source name:
B. ovis cells
Platform:
GPL33317
Series:
GSE262183
Download data
Sample
Accession:
GSM8159234
ID:
308159234
17.

WT_SDS replicate 2 [WT_449_S32]

Organism:
Brucella ovis
Source name:
B. ovis cells
Platform:
GPL33317
Series:
GSE262183
Download data
Sample
Accession:
GSM8159233
ID:
308159233
18.

WT_SDS replicate 1 [WT_448_S31]

Organism:
Brucella ovis
Source name:
B. ovis cells
Platform:
GPL33317
Series:
GSE262183
Download data
Sample
Accession:
GSM8159232
ID:
308159232
19.

∆BOV_1602 replicate 3 [1602_444_S27]

Organism:
Brucella ovis
Source name:
B. ovis cells
Platform:
GPL33317
Series:
GSE262183
Download data
Sample
Accession:
GSM8159231
ID:
308159231
20.

∆BOV_1602 replicate 2 [1602_443_S26]

Organism:
Brucella ovis
Source name:
B. ovis cells
Platform:
GPL33317
Series:
GSE262183
Download data
Sample
Accession:
GSM8159230
ID:
308159230
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