GEO DataSets

(Submitter supplied) The impact of digestive physicochemical parameters on Cryptosporidium parvum transcriptome was analysed in a human and age-dependent context using a dynamic in vitro gastrointestinal model. The sophisticated TIM-1 in vitro model was used for a comparative analysis of C. parvum gene expression under the digestive conditions encountered in young children (from 6 months to 2 years) or in adults following the simulated ingestion of a glass of water contaminated with C. more...

Organism:

Cryptosporidium parvum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26382

15 Samples

Download data: TXT

(Submitter supplied) The parasite Cryptosporidium is a leading agent of diarrheal disease in young children, and a cause and consequence of chronic malnutrition. There are no vaccines and only limited treatment options. The parasite infects enterocytes, where it engages in asexual and sexual replication, both of which are essential to continued infection and transmission. However, their molecular mechanisms remain largely unknown. more...

Organism:

Cryptosporidium parvum

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL34324 GPL26382

22 Samples

Download data: CSV, MTX, RDS, TSV, TXT

(Submitter supplied) To enable functional studies of essential genes in the parasite Cryptosporidium, we developed and validated a rapamycin inducible Cre-recombinase system and used this approach to conditionally ablate the AP2-F transcription factor. Conditional knock out of AP2-F showed that this factor is dispensable for asexual growth and early female fate determination in vitro but that oocyst shedding is blocked in vivo. more...

Organism:

Cryptosporidium parvum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26382

12 Samples

Download data: TXT

(Submitter supplied) The apicomplexan parasite Cryptosporidium is a leading global cause of severe diarrheal disease and an important contributor to early childhood mortality. Currently there are no fully effective treatments or vaccines available. Transmission of the disease occurs through ingestion of oocysts, through direct contact or contaminated water or food. Oocysts are meiotic spores and the product of parasite sex. more...

Organism:

Cryptosporidium parvum

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL26383 GPL26382

21 Samples

Download data: TXT

(Submitter supplied) Global gene expression in C. parvum environmental stage (oocysts) and the oocysts treated with UV comparing control untreated ones. Goal was to uncover the metabolic features in oocysts and the oocysts treated with UV.

Organism:

Cryptosporidium parvum

Type:

Expression profiling by array

Platform:

GPL14756

8 Samples

Download data: TXT

(Submitter supplied) probes was in situ synthesized.

Organism:

Cryptosporidium parvum

1 Series

8 Samples

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