GEO DataSets

(Submitter supplied) The bacteria in the chlamydiales order are obligate intracellular parasites of eukaryotic cells. They are reliant on an infectious cycle consisting of at least three phenotypically distinct cell forms termed the reticulate body (RB), the intermediate body (IB) and the elementary body (EB). The EB is infectious but does not replicate. The RB replicates in the host cell but is non-infectious, while the IB is an intermediate form that transitions to the EB form. more...

Organism:

Chlamydia trachomatis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL34870

8 Samples

Download data: TXT

(Submitter supplied) The pathogenic bacterium Chlamydia reproduces via an unusual intracellular developmental cycle in which it converts from a dividing form (reticulate body or RB) to an infectious form (elementary body or EB). The transcription factor Euo has been proposed as a developmental regulator in C. trachomatis because it repressed a number of late chlamydial promoters, which are transcribed during RB-to-EB conversion. more...

Organism:

Chlamydia trachomatis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL32238

18 Samples

Download data: XLSX

(Submitter supplied) The bacteria in the chlamydiales order are obligate intracellular parasites of eukaryotic cells. They are reliant on an infectious cycle consisting of at least three phenotypically distinct cell forms termed the reticulate body (RB), the intermediate body (IB) and the elementary body (EB). The EB is infectious but does not replicate. The RB replicates in the host cell but is non-infectious, while the IB is an intermediate form that transitions to the EB form. more...

Organism:

Chlamydia trachomatis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28812

30 Samples

Download data: TXT

(Submitter supplied) The obligate intracellular bacterium Chlamydia has a unique developmental cycle that alternates between two contrasting cell types. With a hardy envelope and highly condensed genome, the small elementary body (EB) maintains limited metabolic activities yet can survive in an extracellular environment and is infectious. After entering host cells, EBs differentiate into larger and proliferating reticulate bodies (RBs). more...

Organism:

Chlamydia trachomatis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28812

12 Samples

Download data: TXT

(Submitter supplied) To determine the role that GrgA plays in chlamydial physiology, we constructed a Chlamydia trachomatis mutant that we term L/cgad-peig, in which the chromosomal grgA (ctl0766 or ct504) has been disrupted by Targetron mutagenesis, and the plasmid carries an inducible grgA under the control of anhydrotetracycline (ATC). RNA-Seq analysis was performed for L2/cgad-peig grown with and without ATC.

Organism:

Chlamydia trachomatis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL32238

12 Samples

Download data: TXT

(Submitter supplied) RNAseq analysis was performed for C. trachomatis serovar L2 after knocking down or overexpressing different sigma factors.

Organism:

Chlamydia trachomatis L2/434/Bu

Type:

Expression profiling by high throughput sequencing

Platform:

GPL33362

48 Samples

Download data: XLSX

(Submitter supplied) The pathogenic bacterium Chlamydia reproduces via an unusual intracellular developmental cycle in which it converts from a dividing form (reticulate body or RB) to an infectious form (elementary body or EB). The transcription factor Euo has been proposed as a developmental regulator in C. trachomatis because it repressed a number of late chlamydial promoters, which are transcribed during RB-to-EB conversion. more...

Organism:

Chlamydia trachomatis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL32238

16 Samples

Download data: XLSX

(Submitter supplied) The pathogenic bacterium Chlamydia reproduces via an unusual intracellular developmental cycle in which it converts from a dividing form (reticulate body or RB) to an infectious form (elementary body or EB). The transcription factor Euo has been proposed as a developmental regulator in C. trachomatis because it repressed a number of late chlamydial promoters, which are transcribed during RB-to-EB conversion. more...

Organism:

Chlamydia trachomatis

Type:

Other

Platform:

GPL32238

8 Samples

Download data: XLSX

(Submitter supplied) We utilized host-pathogen dual RNA-sequencing to elucidate the transcriptomes of both Chlamydia trachomatis and the infected HeLa cell during nutritional conditions that induce persistence.

Organism:

Chlamydia trachomatis L2/434/Bu; Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL30321 GPL30320

18 Samples

Download data: CSV

(Submitter supplied) Heat shock-induced transcriptomic response in Chlamydia trachomatis

Organism:

Chlamydia trachomatis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28812

6 Samples

Download data: FA, GTF, TXT

(Submitter supplied) Effects of overexpression of Chlamydia trachomatis transcription factors GrgA, Euo and HrcA on the chlamydial transcriptome were determined.

Organism:

Chlamydia trachomatis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28812

36 Samples

Download data: TXT

(Submitter supplied) Chlamydia trachomatis D serovar was grown in axenic culture with G6P or G6P with glutamine. The data reveal the early transcriptonal regulation in the bacteria.

Organism:

Chlamydia trachomatis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28305

9 Samples

Download data: TXT

(Submitter supplied) To identify immunodominant antigens that elicit a humoral immune response following a primary genital infection, rhesus monkeys were inoculated cervically with Chlamydia trachomatis serovar D. Serum samples were collected and probed with a protein microarray expressing 864/894 (96.4%) of the open reading frames of the C. trachomatis serovar D genome. The antibody response was analyzed in 72 serum samples from 12 inoculated monkeys. more...

Organism:

Chlamydia trachomatis; Macaca mulatta

Type:

Protein profiling by protein array

Platform:

GPL28497

72 Samples

Download data: TXT

(Submitter supplied) The pathogenic spirochete Borrelia burgdorferi senses and responds to diverse environmental challenges, including changes in nutrient availability, throughout its natural infectious cycle in Ixodes spp. ticks and mammalian hosts. This study examined the role of the putative DnaK suppressor protein (DksA) in the transcriptional response of B. burgdorferi to starvation. Wild-type and dksA-deficient B. more...

Organism:

Yersinia pestis; Borreliella burgdorferi; Chlamydia trachomatis; Staphylococcus aureus; Coxiella burnetii; Streptococcus pyogenes

Type:

Expression profiling by array

Platform:

GPL2129

12 Samples

Download data: CEL, CHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Chlamydia trachomatis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24258

28 Samples

Download data

(Submitter supplied) Mid-cycle C. trachomatis differentially regulates a subset of genes in response to iron-starvation

Organism:

Chlamydia trachomatis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24258

20 Samples

Download data: XLSX

(Submitter supplied) Early-cycle C. trachomatis differentially regulates a subset of genes in response to iron-starvation

Organism:

Chlamydia trachomatis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24258

8 Samples

Download data: XLSX

(Submitter supplied) Several methicillin resistance (SCCmec) clusters characteristic of hospital-associated methicillin-resistant Staphylococcus aureus (MRSA) strains harbor the psm-mec locus. In addition to encoding the cytolysin, phenol-soluble modulin (PSM) mec, this locus has been attributed gene regulatory functions. Here we employed genome-wide transcriptional profiling to define the regulatory function of the psm-mec locus. more...

Organism:

Staphylococcus aureus; Coxiella burnetii; Borreliella burgdorferi; Chlamydia trachomatis; Yersinia pestis; Streptococcus pyogenes

Type:

Expression profiling by array

Platform:

GPL2129

12 Samples

Download data: CEL, CHP

(Submitter supplied) The Yersinia pestis PhoPQ gene regulatory system is induced during infection of the flea digestive tract and is required to produce adherent biofilm in the foregut, which greatly enhances bacterial transmission during a flea bite. To understand the in vivo context of PhoPQ induction and to determine PhoP-regulated targets in the flea, we undertook whole genome comparative transcriptional profiling of Y. more...

Organism:

Yersinia pestis; Coxiella burnetii; Chlamydia trachomatis; Streptococcus pyogenes; Borreliella burgdorferi; Staphylococcus aureus

Type:

Expression profiling by array

Platform:

GPL2129

40 Samples

Download data: CEL, CHP

(Submitter supplied) Bacterial sepsis is a major killer in hospitalized patients. Coagulase-negative staphylococci (CNS) with the leading species Staphylococcus epidermidis are the most frequent causes of nosocomial sepsis, with most infectious isolates being methicillin resistant. However, which bacterial factors underlie the pathogenesis of CNS sepsis is unknown. While it has been commonly believed that invariant structures on the surface of CNS trigger sepsis by causing an over-reaction of the immune system, we show here that sepsis caused my methicillin-resistant S. more...

Organism:

Staphylococcus epidermidis ATCC 12228; Chlamydia trachomatis D/UW-3/CX; Coxiella burnetii; Rickettsia rickettsii; Chlamydia muridarum; Staphylococcus epidermidis RP62A; Staphylococcus epidermidis; Staphylococcus aureus subsp. aureus MW2; Granulibacter bethesdensis; Chlamydia pneumoniae AR39; Borreliella burgdorferi B31; Coxiella burnetii RSA 493; Chlamydia caviae GPIC; Staphylococcus haemolyticus JCSC1435

Type:

Expression profiling by array

Platform:

GPL4692

15 Samples

Download data: CEL, CHP