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Ciz1 CDKN1A interacting zinc finger protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296639, updated on 10-Jul-2024

Summary

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Official Symbol
Ciz1provided by RGD
Official Full Name
CDKN1A interacting zinc finger protein 1provided by RGD
Primary source
RGD:1305336
See related
EnsemblRapid:ENSRNOG00000013442 AllianceGenome:RGD:1305336
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cyclin binding activity. Predicted to act upstream of or within maintenance of protein location in nucleus and positive regulation of DNA-dependent DNA replication initiation. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in nucleus. Orthologous to human CIZ1 (CDKN1A interacting zinc finger protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 58.9), Heart (RPKM 58.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ciz1 in Genome Data Viewer
Location:
3p12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (36055753..36071510)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (15658479..15673762)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11392046..11409218)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene golgin A2 Neighboring gene dynamin 1 Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC134486070 Neighboring gene bublin coiled coil protein Neighboring gene lipocalin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. C-terminal domains deliver the DNA replication factor Ciz1 to the nuclear matrix. Ainscough JF, et al. J Cell Sci, 2007 Jan 1. PMID 17182902
  2. Ciz1 promotes mammalian DNA replication. Coverley D, et al. J Cell Sci, 2005 Jan 1. PMID 15585571
  3. Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro. Copeland NA, et al. J Cell Sci, 2010 Apr 1. PMID 20215406, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within maintenance of protein location in nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated DNA replication initiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cip1-interacting zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399357.1 → NP_001386286.1  cip1-interacting zinc finger protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    B2RYH1, F1LS75
    Conserved Domains (4) summary
    smart00451
    Location:485 → 517
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:93 → 403
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:549 → 569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:579 → 603
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  2. NM_001399358.1 → NP_001386287.1  cip1-interacting zinc finger protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6AJV2, B2RYH1
    Related
    ENSRNOP00000035313.8, ENSRNOT00000037399.8
    Conserved Domains (4) summary
    smart00451
    Location:481 → 513
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:93 → 399
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:545 → 565
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:575 → 599
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  3. NM_001399359.1 → NP_001386288.1  cip1-interacting zinc finger protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    B2RYH1
    Conserved Domains (4) summary
    smart00451
    Location:388 → 420
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:2 → 306
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:452 → 472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:482 → 506
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    36055753..36071510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008761719.4 → XP_008759941.2  cip1-interacting zinc finger protein isoform X6

    UniProtKB/TrEMBL
    B2RYH1
    Conserved Domains (4) summary
    smart00451
    Location:476 → 508
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:93 → 394
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:540 → 560
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:570 → 594
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  2. XM_006233941.5 → XP_006234003.1  cip1-interacting zinc finger protein isoform X1

    See identical proteins and their annotated locations for XP_006234003.1

    UniProtKB/TrEMBL
    A6JU56, F1LV60
    Conserved Domains (4) summary
    smart00451
    Location:532 → 564
    ZnF_U1; U1-like zinc finger
    COG5112
    Location:606 → 657
    UFD2; U1-like Zn-finger-containing protein [General function prediction only]
    sd00020
    Location:596 → 616
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:626 → 650
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  3. XM_063283494.1 → XP_063139564.1  cip1-interacting zinc finger protein isoform X3

    UniProtKB/TrEMBL
    B2RYH1, F1LS75

  4. XM_063283496.1 → XP_063139566.1  cip1-interacting zinc finger protein isoform X4

    UniProtKB/TrEMBL
    A0A8I6AJV2, B2RYH1

  5. XM_006233943.4 → XP_006234005.1  cip1-interacting zinc finger protein isoform X2

    UniProtKB/TrEMBL
    A6JU56
    Conserved Domains (4) summary
    smart00451
    Location:527 → 559
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:109 → 456
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:591 → 611
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:621 → 645
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  6. XM_063283497.1 → XP_063139567.1  cip1-interacting zinc finger protein isoform X5

    UniProtKB/TrEMBL
    B2RYH1

  7. XM_063283499.1 → XP_063139569.1  cip1-interacting zinc finger protein isoform X6

    UniProtKB/TrEMBL
    B2RYH1

  8. XM_063283500.1 → XP_063139570.1  cip1-interacting zinc finger protein isoform X7

    UniProtKB/TrEMBL
    A6JU56

  9. XM_063283501.1 → XP_063139571.1  cip1-interacting zinc finger protein isoform X8

    UniProtKB/TrEMBL
    B2RYH1

  10. XM_063283502.1 → XP_063139572.1  cip1-interacting zinc finger protein isoform X9

    UniProtKB/TrEMBL
    B2RYH1

  11. XM_063283503.1 → XP_063139573.1  cip1-interacting zinc finger protein isoform X10

    UniProtKB/TrEMBL
    B2RYH1

  12. XM_063283504.1 → XP_063139574.1  cip1-interacting zinc finger protein isoform X11

  13. XM_006233940.4 → XP_006234002.1  cip1-interacting zinc finger protein isoform X1

    See identical proteins and their annotated locations for XP_006234002.1

    UniProtKB/TrEMBL
    A6JU56, F1LV60
    Related
    ENSRNOP00000083181.1, ENSRNOT00000107806.2
    Conserved Domains (4) summary
    smart00451
    Location:532 → 564
    ZnF_U1; U1-like zinc finger
    COG5112
    Location:606 → 657
    UFD2; U1-like Zn-finger-containing protein [General function prediction only]
    sd00020
    Location:596 → 616
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:626 → 650
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  14. XM_008761715.3 → XP_008759937.2  cip1-interacting zinc finger protein isoform X2

    UniProtKB/TrEMBL
    A6JU56
    Conserved Domains (4) summary
    smart00451
    Location:527 → 559
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:109 → 456
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:591 → 611
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:621 → 645
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  15. XM_063283498.1 → XP_063139568.1  cip1-interacting zinc finger protein isoform X5

    UniProtKB/TrEMBL
    B2RYH1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106568.1: Suppressed sequence

    Description
    NM_001106568.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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