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svila supervillin a [ Danio rerio (zebrafish) ]

Gene ID: 30112, updated on 12-Sep-2024

Summary

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Official Symbol
svilaprovided by ZNC
Official Full Name
supervillin aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990706-5
See related
Ensembl:ENSDARG00000055075 AllianceGenome:ZFIN:ZDB-GENE-990706-5
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
svil; sb:cb867; wu:fd05a09
Summary
Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to act upstream of or within cytoskeleton organization. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in several structures, including adaxial cell; cardiovascular system; musculature system; optic vesicle; and sensory system. Human ortholog(s) of this gene implicated in myofibrillar myopathy 10. Orthologous to human SVIL (supervillin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See svila in Genome Data Viewer
Location:
chromosome: 12
Exon count:
45
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (23812531..23932576)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (23691312..23811357)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene mitochondrial poly(A) polymerase Neighboring gene junctional cadherin 5 associated a Neighboring gene proteasome activator subunit 4b Neighboring gene ChaC, cation transport regulator homolog 2 (E. coli)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Prioritizing causal disease genes using unbiased genomic features. Deo RC, et al. Genome Biol, 2014 Dec 3. PMID 25633252, Free PMC Article
  2. Supervillin Is a Component of the Hair Cell's Cuticular Plate and the Head Plates of Organ of Corti Supporting Cells. Pollock LM, et al. PLoS One, 2016. PMID 27415442, Free PMC Article
  3. Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines. Lam SH, et al. BMC Med Genomics, 2011 May 16. PMID 21575170, Free PMC Article
  4. Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. Gallagher TL, et al. Dev Biol, 2011 Nov 15. PMID 21925157, Free PMC Article
  5. Identification of vasculature-specific genes by microarray analysis of Etsrp/Etv2 overexpressing zebrafish embryos. Wong KS, et al. Dev Dyn, 2009 Jul. PMID 19504456

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
supervillin a
Names
zmp:0000000648

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035261.2 → NP_001030338.2  supervillin a isoform 2

    Status: VALIDATED

    Source sequence(s)
    CU914155, DQ227765
    UniProtKB/TrEMBL
    A0A8M1N7Y6, F1Q6K8, Q38HW9
    Related
    ENSDARP00000066330.4, ENSDART00000066331.7
    Conserved Domains (6) summary
    cd11280
    Location:1108 → 1208
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1424 → 1527
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:987 → 1083
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1291 → 1402
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:1722 → 1763
    VHP; Villin headpiece domain
    cl15697
    Location:1544 → 1665
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  2. NM_001430943.1 → NP_001417872.1  supervillin a isoform 1

    Status: VALIDATED

    Source sequence(s)
    BX005400, CU914155
    UniProtKB/TrEMBL
    A0A8M9QII8

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    23812531..23932576
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480012.2 → XP_021335687.1  supervillin a isoform X1

    UniProtKB/TrEMBL
    A0A8M9PW23
    Conserved Domains (6) summary
    cd11280
    Location:1586 → 1686
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1902 → 2005
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1465 → 1561
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1769 → 1880
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:2200 → 2241
    VHP; Villin headpiece domain
    cl15697
    Location:2022 → 2143
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  2. XM_021480014.2 → XP_021335689.1  supervillin a isoform X3

    UniProtKB/TrEMBL
    A0A8M9QE30
    Conserved Domains (6) summary
    cd11280
    Location:1553 → 1653
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1869 → 1972
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1432 → 1528
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1736 → 1847
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:2167 → 2208
    VHP; Villin headpiece domain
    cl15697
    Location:1989 → 2110
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  3. XM_021480013.2 → XP_021335688.1  supervillin a isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q864
    Conserved Domains (6) summary
    cd11280
    Location:1584 → 1684
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1900 → 2003
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1463 → 1559
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1767 → 1878
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:2198 → 2239
    VHP; Villin headpiece domain
    cl15697
    Location:2020 → 2141
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  4. XM_021480015.2 → XP_021335690.1  supervillin a isoform X4

    UniProtKB/TrEMBL
    A0A8M9QMC6, Q38HW9
    Conserved Domains (6) summary
    cd11280
    Location:1264 → 1364
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1580 → 1683
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1143 → 1239
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1447 → 1558
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:1878 → 1919
    VHP; Villin headpiece domain
    cl15697
    Location:1700 → 1821
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  5. XM_021480016.2 → XP_021335691.1  supervillin a isoform X5

    UniProtKB/TrEMBL
    A0A8M9QIJ4, Q38HW9
    Conserved Domains (6) summary
    cd11280
    Location:1192 → 1292
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1508 → 1611
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1071 → 1167
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1375 → 1486
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:1806 → 1847
    VHP; Villin headpiece domain
    cl15697
    Location:1628 → 1749
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  6. XM_068224487.1 → XP_068080588.1  supervillin a isoform X6

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394842.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    179054..301525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395302.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    859..68890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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