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Pcnt pericentrin [ Rattus norvegicus (Norway rat) ]

Gene ID: 309692, updated on 6-Jun-2024

Summary

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Official Symbol
Pcntprovided by RGD
Official Full Name
pericentrinprovided by RGD
Primary source
RGD:1595865
See related
Ensembl:ENSRNOG00000001276 AllianceGenome:RGD:1595865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable molecular adaptor activity. Predicted to be involved in microtubule cytoskeleton organization and positive regulation of intracellular protein transport. Predicted to act upstream of or within several processes, including animal organ development; mitotic spindle organization; and neuron migration. Predicted to be located in several cellular components, including cis-Golgi network; intercellular bridge; and microtubule organizing center. Human ortholog(s) of this gene implicated in microcephalic osteodysplastic primordial dwarfism type II. Orthologous to human PCNT (pericentrin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 102.2), Heart (RPKM 83.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pcnt in Genome Data Viewer
Location:
20p12
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (12189767..12278179)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (12190597..12278723)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (12943523..13038615)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene minichromosome maintenance complex component 3 associated protein Neighboring gene similar to human chromosome 21 open reading frame 58 Neighboring gene ybeY metalloendoribonuclease Neighboring gene uncharacterized LOC134483886 Neighboring gene disco-interacting protein 2 homolog A Neighboring gene uncharacterized LOC134483887 Neighboring gene U6 spliceosomal RNA Neighboring gene S100 calcium binding protein B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Pericentrin expression in Down's syndrome. Salemi M, et al. Neurol Sci, 2013 Nov. PMID 23979692
  2. The smallest teeth in the world are caused by mutations in the PCNT gene. Kantaputra P, et al. Am J Med Genet A, 2011 Jun. PMID 21567919
  3. Molecular analysis of pericentrin gene (PCNT) in a series of 24 Seckel/microcephalic osteodysplastic primordial dwarfism type II (MOPD II) families. Willems M, et al. J Med Genet, 2010 Dec. PMID 19643772
  4. Mutations in the pericentrin (PCNT) gene cause primordial dwarfism. Rauch A, et al. Science, 2008 Feb 8. PMID 18174396
  5. Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. Griffith E, et al. Nat Genet, 2008 Feb. PMID 18157127, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within brain morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within camera-type eye development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cerebellar cortex morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic brain development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic heart tube development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within head development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within limb morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within olfactory bulb development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spindle organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within vasculature development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule organizing center ISO
Inferred from Sequence Orthology
more info
  
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in pericentriolar material ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pericentrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427002.1 → NP_001413931.1  pericentrin

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    D3ZMY8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    12189767..12278179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099203.2 → XP_038955131.1  pericentrin isoform X1

    UniProtKB/TrEMBL
    D3ZMY8
    Conserved Domains (4) summary
    PTZ00121
    Location:154 → 858
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:1310 → 1561
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:1043 → 1434
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10495
    Location:2754 → 2832
    PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

  2. XM_039099208.2 → XP_038955136.1  pericentrin isoform X8

    UniProtKB/TrEMBL
    D3ZMY8
    Conserved Domains (4) summary
    PTZ00121
    Location:154 → 858
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:1310 → 1561
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:1043 → 1434
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10495
    Location:2714 → 2792
    PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

  3. XM_039099209.2 → XP_038955137.1  pericentrin isoform X10

    UniProtKB/TrEMBL
    D3ZMY8
    Conserved Domains (4) summary
    PTZ00121
    Location:154 → 858
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:2137 → 2479
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:1043 → 1434
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10495
    Location:2677 → 2755
    PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

  4. XM_063279161.1 → XP_063135231.1  pericentrin isoform X13

    UniProtKB/TrEMBL
    D3ZMY8

  5. XM_017601880.3 → XP_017457369.1  pericentrin isoform X6

    UniProtKB/TrEMBL
    D3ZMY8

  6. XM_063279159.1 → XP_063135229.1  pericentrin isoform X9

    UniProtKB/TrEMBL
    D3ZMY8

  7. XM_039099210.2 → XP_038955138.1  pericentrin isoform X11

    UniProtKB/TrEMBL
    D3ZMY8
    Related
    ENSRNOP00000039329.5
    Conserved Domains (4) summary
    PTZ00121
    Location:154 → 858
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:2137 → 2461
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:1043 → 1434
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10495
    Location:2659 → 2737
    PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

  8. XM_063279162.1 → XP_063135232.1  pericentrin isoform X14

    UniProtKB/TrEMBL
    D3ZMY8

  9. XM_039099205.2 → XP_038955133.1  pericentrin isoform X3

    UniProtKB/TrEMBL
    D3ZMY8
    Conserved Domains (4) summary
    PTZ00121
    Location:154 → 858
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:1316 → 1554
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:1043 → 1427
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10495
    Location:2747 → 2825
    PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

  10. XM_039099206.2 → XP_038955134.1  pericentrin isoform X4

    UniProtKB/TrEMBL
    D3ZMY8
    Conserved Domains (4) summary
    PTZ00121
    Location:154 → 858
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:1299 → 1550
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:1043 → 1423
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10495
    Location:2743 → 2821
    PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

  11. XM_006256312.5 → XP_006256374.1  pericentrin isoform X18

    See identical proteins and their annotated locations for XP_006256374.1

    UniProtKB/TrEMBL
    D3ZMY8
    Related
    ENSRNOP00000095505.1
    Conserved Domains (7) summary
    TIGR02168
    Location:462 → 1423
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam07106
    Location:1297 → 1405
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
    pfam09455
    Location:1050 → 1217
    Cas_DxTHG; CRISPR-associated (Cas) DxTHG family
    pfam10495
    Location:2725 → 2803
    PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    pfam12474
    Location:156 → 310
    PKK; Polo kinase kinase
    cd16269
    Location:311 → 321
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:198 → 345
    GBP_C; Guanylate-binding protein, C-terminal domain

  12. XM_063279160.1 → XP_063135230.1  pericentrin isoform X12

    UniProtKB/TrEMBL
    D3ZMY8

  13. XM_039099204.2 → XP_038955132.1  pericentrin isoform X2

    UniProtKB/TrEMBL
    D3ZMY8
    Conserved Domains (3) summary
    COG1196
    Location:158 → 533
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:462 → 1433
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10495
    Location:2753 → 2831
    PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

  14. XM_039099207.2 → XP_038955135.1  pericentrin isoform X5

    UniProtKB/TrEMBL
    D3ZMY8
    Conserved Domains (3) summary
    COG1196
    Location:158 → 533
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:462 → 1422
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10495
    Location:2742 → 2820
    PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

  15. XM_002728936.6 → XP_002728982.2  pericentrin isoform X17

    See identical proteins and their annotated locations for XP_002728982.2

    UniProtKB/TrEMBL
    D3ZMY8
    Conserved Domains (7) summary
    TIGR02168
    Location:462 → 1422
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam07106
    Location:1296 → 1404
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
    pfam09455
    Location:1049 → 1216
    Cas_DxTHG; CRISPR-associated (Cas) DxTHG family
    pfam10495
    Location:2647 → 2725
    PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    pfam12474
    Location:156 → 310
    PKK; Polo kinase kinase
    cd16269
    Location:311 → 321
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:198 → 345
    GBP_C; Guanylate-binding protein, C-terminal domain

  16. XM_063279158.1 → XP_063135228.1  pericentrin isoform X7

    UniProtKB/TrEMBL
    D3ZMY8

  17. XM_063279163.1 → XP_063135233.1  pericentrin isoform X15

    UniProtKB/TrEMBL
    A0A8I6ANK0

  18. XM_039099211.2 → XP_038955139.1  pericentrin isoform X16

    Conserved Domains (3) summary
    COG0419
    Location:108 → 645
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    TIGR02168
    Location:1391 → 1643
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10495
    Location:1835 → 1913
    PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
Nucleotide Protein Strain
Heading Accession and Version

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