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mms22l MMS22-like, DNA repair protein [ Danio rerio (zebrafish) ]

Gene ID: 563411, updated on 28-Oct-2024

Summary

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Official Symbol
mms22lprovided by ZNC
Official Full Name
MMS22-like, DNA repair proteinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3869
See related
Ensembl:ENSDARG00000074691 AllianceGenome:ZFIN:ZDB-GENE-030131-3869
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc56d09; wu:fc56d09; zgc:194596
Summary
Predicted to enable single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination and replication fork processing. Predicted to act upstream of or within DNA repair and chromatin organization. Predicted to be located in chromosome and nucleus. Predicted to be part of FACT complex and MCM complex. Predicted to be active in nuclear replication fork and site of DNA damage. Orthologous to human MMS22L (MMS22 like, DNA repair protein). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See mms22l in Genome Data Viewer
Location:
chromosome: 16
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (32281430..32304764, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (32327401..32350803, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene calcium homeostasis modulator family member 6 Neighboring gene kelch-like family member 32 Neighboring gene uncharacterized LOC137487924 Neighboring gene uncharacterized LOC137487845

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Pnrc2 regulates 3'UTR-mediated decay of segmentation clock-associated transcripts during zebrafish segmentation. Gallagher TL, et al. Dev Biol, 2017 Sep 1. PMID 28648842, Free PMC Article
  2. Pou3f transcription factor expression during embryonic development highlights distinct pou3f3 and pou3f4 localization in the Xenopus laevis kidney. Cosse-Etchepare C, et al. Int J Dev Biol, 2018. PMID 29877572
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in replication fork processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within replication fork processing IEA
Inferred from Electronic Annotation
more info
  
involved_in replication fork processing ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of FACT complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of MCM complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear replication fork IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear replication fork ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in site of DNA damage ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein MMS22-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130601.1 → NP_001124073.1  protein MMS22-like

    See identical proteins and their annotated locations for NP_001124073.1

    Status: PROVISIONAL

    Source sequence(s)
    BC163291
    UniProtKB/Swiss-Prot
    B3DIY3
    Related
    ENSDARP00000155250.1, ENSDART00000191408.1
    Conserved Domains (2) summary
    pfam14910
    Location:29 → 739
    MMS22L_N; S-phase genomic integrity recombination mediator, N-terminal
    pfam14911
    Location:851 → 1226
    MMS22L_C; S-phase genomic integrity recombination mediator, C-terminal

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    32281430..32304764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158355.5 → XP_005158412.1  protein MMS22-like isoform X1

    See identical proteins and their annotated locations for XP_005158412.1

    UniProtKB/TrEMBL
    A0A8M9P7Y3, F1Q905
    Related
    ENSDARP00000115566.1, ENSDART00000134381.2
    Conserved Domains (2) summary
    pfam14910
    Location:29 → 739
    MMS22L_N; S-phase genomic integrity recombination mediator, N-terminal
    pfam14911
    Location:851 → 1226
    MMS22L_C; S-phase genomic integrity recombination mediator, C-terminal

  2. XM_021466713.2 → XP_021322388.1  protein MMS22-like isoform X1

    UniProtKB/TrEMBL
    A0A8M9P7Y3, F1Q905
    Conserved Domains (2) summary
    pfam14910
    Location:29 → 739
    MMS22L_N; S-phase genomic integrity recombination mediator, N-terminal
    pfam14911
    Location:851 → 1226
    MMS22L_C; S-phase genomic integrity recombination mediator, C-terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B3DIY3.1 GenPept UniProtKB/Swiss-Prot:B3DIY3

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