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    Cep57 centrosomal protein 57 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315423, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Cep57provided by RGD
    Official Full Name
    centrosomal protein 57provided by RGD
    Primary source
    RGD:1309884
    See related
    EnsemblRapid:ENSRNOG00000006792 AllianceGenome:RGD:1309884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309884; 3110002l15rik
    Summary
    Predicted to enable fibroblast growth factor binding activity; microtubule binding activity; and protein homodimerization activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway and protein homooligomerization. Predicted to act upstream of or within spermatid development. Predicted to be located in Golgi apparatus; microtubule; and nucleus. Predicted to be active in centrosome. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome 2. Orthologous to human CEP57 (centrosomal protein 57). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 131.4), Thymus (RPKM 120.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    8q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (18951179..18971205, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (10669588..10689257, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (12335430..12355425, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene mastermind-like transcriptional coactivator 2 Neighboring gene uncharacterized LOC120094078 Neighboring gene myotubularin related protein 2 Neighboring gene family with sequence similarity 76, member B Neighboring gene uncharacterized LOC134480141 Neighboring gene uncharacterized LOC134480142

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cep57, a multidomain protein with unique microtubule and centrosomal localization domains. Momotani K, et al. Biochem J, 2008 Jun 1. PMID 18294141, Free PMC Article
    2. Tsp57: a novel gene induced during a specific stage of spermatogenesis. Kim YS, et al. Biol Reprod, 2004 Jan. PMID 12954732
    3. Translokin is an intracellular mediator of FGF-2 trafficking. Bossard C, et al. Nat Cell Biol, 2003 May. PMID 12717444
    4. Proteomic characterization of the human centrosome by protein correlation profiling. Andersen JS, et al. Nature, 2003 Dec 4. PMID 14654843
    5. A visual intracellular classification strategy for uncharacterized human proteins. Hoja MR, et al. Exp Cell Res, 2000 Aug 25. PMID 10942595

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fibroblast growth factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 57 kDa
    Names
    centrosomal protein 57kDa
    translokin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108124.3 → NP_001101594.2  centrosomal protein of 57 kDa

      See identical proteins and their annotated locations for NP_001101594.2

      Status: VALIDATED

      Source sequence(s)
      BC168198, BI291153, CB807650
      UniProtKB/Swiss-Prot
      B4F7A7
      UniProtKB/TrEMBL
      A0A8I6A259, A6JN77
      Related
      ENSRNOP00000009318.6, ENSRNOT00000009318.8
      Conserved Domains (2) summary
      pfam06657
      Location:351 → 419
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:68 → 245
      Cep57_CLD; Centrosome localization domain of Cep57

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      18951179..18971205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242524.5 → XP_006242586.1  centrosomal protein of 57 kDa isoform X1

      See identical proteins and their annotated locations for XP_006242586.1

      UniProtKB/TrEMBL
      A0A8I6A259
      Conserved Domains (2) summary
      pfam06657
      Location:324 → 393
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:41 → 218
      Cep57_CLD; Centrosome localization domain of Cep57

    2. XM_039081340.2 → XP_038937268.1  centrosomal protein of 57 kDa isoform X1

      UniProtKB/TrEMBL
      A0A8I6A259
      Conserved Domains (2) summary
      pfam06657
      Location:324 → 393
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:41 → 218
      Cep57_CLD; Centrosome localization domain of Cep57

    3. XM_006242523.5 → XP_006242585.1  centrosomal protein of 57 kDa isoform X1

      See identical proteins and their annotated locations for XP_006242585.1

      UniProtKB/TrEMBL
      A0A8I6A259
      Conserved Domains (2) summary
      pfam06657
      Location:324 → 393
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:41 → 218
      Cep57_CLD; Centrosome localization domain of Cep57

    4. XM_063265328.1 → XP_063121398.1  centrosomal protein of 57 kDa isoform X1

      UniProtKB/TrEMBL
      A0A8I6A259
      Related
      ENSRNOP00000085671.1, ENSRNOT00000111369.2

    5. XM_039081342.2 → XP_038937270.1  centrosomal protein of 57 kDa isoform X2

      Conserved Domains (2) summary
      pfam06657
      Location:202 → 271
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:5 → 96
      Cep57_CLD; Centrosome localization domain of Cep57

    6. XM_039081348.2 → XP_038937276.1  centrosomal protein of 57 kDa isoform X5

      Conserved Domains (2) summary
      pfam06657
      Location:142 → 211
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:1 → 36
      Cep57_CLD; Centrosome localization domain of Cep57

    7. XM_039081341.2 → XP_038937269.1  centrosomal protein of 57 kDa isoform X3

      UniProtKB/TrEMBL
      A6JN79
      Conserved Domains (2) summary
      pfam06657
      Location:202 → 271
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:1 → 96
      Cep57_CLD; Centrosome localization domain of Cep57

    8. XM_039081343.2 → XP_038937271.1  centrosomal protein of 57 kDa isoform X4

      Conserved Domains (2) summary
      pfam06657
      Location:150 → 219
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:1 → 44
      Cep57_CLD; Centrosome localization domain of Cep57
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B4F7A7.2 GenPept UniProtKB/Swiss-Prot:B4F7A7

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