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    NFKBID NFKB inhibitor delta [ Homo sapiens (human) ]

    Gene ID: 84807, updated on 2-Nov-2024

    Summary

    Official Symbol
    NFKBIDprovided by HGNC
    Official Full Name
    NFKB inhibitor deltaprovided by HGNC
    Primary source
    HGNC:HGNC:15671
    See related
    Ensembl:ENSG00000167604 MIM:618887; AllianceGenome:HGNC:15671
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IkBNS; TA-NFKBH; IkappaBNS
    Summary
    Predicted to enable NF-kappaB binding activity. Predicted to be involved in T cell receptor signaling pathway; positive regulation of T-helper 17 cell differentiation; and regulation of gene expression. Predicted to act upstream of or within several processes, including negative regulation of NF-kappaB transcription factor activity; negative regulation of canonical NF-kappaB signal transduction; and positive regulation of thymocyte apoptotic process. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bone marrow (RPKM 9.7), appendix (RPKM 2.8) and 19 other tissues See more
    Orthologs
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    Genomic context

    See NFKBID in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35887952..35902303, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38433711..38448068, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36378854..36393205, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985317 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10541 Neighboring gene amyloid beta precursor like protein 1 Neighboring gene uncharacterized LOC124904705 Neighboring gene RNA, 7SL, cytoplasmic 402, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36389157-36389729 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36389730-36390301 Neighboring gene H3K27ac hESC enhancers GRCh37_chr19:36390314-36390870 and GRCh37_chr19:36390871-36391426 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:36398209-36398362 Neighboring gene hematopoietic cell signal transducer Neighboring gene transmembrane immune signaling adaptor TYROBP

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    General gene information

    Clone Names

    • MGC11314, MGC149503

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway  
    involved_in inflammatory response  
    involved_in positive regulation of T-helper 17 cell differentiation  
    involved_in regulation of gene expression  
    Component Evidence Code Pubs
    is_active_in nucleus  

    General protein information

    Preferred Names
    NF-kappa-B inhibitor delta
    Names
    I-kappa-B-delta
    T-cell activation NFKB-like protein
    ikB-delta
    ikappaBdelta
    nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321831.2NP_001308760.1  NF-kappa-B inhibitor delta isoform 2

      Status: VALIDATED

      Source sequence(s)
      AD000864, CD743210
      UniProtKB/TrEMBL
      A0AAQ5BIF9
      Related
      ENSP00000520477.1, ENST00000715565.1
      Conserved Domains (4) summary
      cd00204
      Location:94242
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00023
      Location:258293
      Ank; Ankyrin repeat
      pfam12796
      Location:104213
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:6397
      ANK; ANK repeat [structural motif]
    2. NM_001365705.1NP_001352634.1  NF-kappa-B inhibitor delta isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (4), formerly known as isoform 1.
      Source sequence(s)
      AD000864
      Consensus CDS
      CCDS42552.1
      UniProtKB/Swiss-Prot
      Q8NI38, Q8NI39, Q9BRG9
      Related
      ENSP00000520478.1, ENST00000585544.2
      Conserved Domains (3) summary
      PHA03095
      Location:46287
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:4882
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:183278
      Ank_2; Ankyrin repeats (3 copies)
    3. NM_001365706.3NP_001352635.2  NF-kappa-B inhibitor delta isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) encodes isoform 5 (formerly known as isoform 4) and uses a non-AUG (CUG) translation initiation codon.
      Source sequence(s)
      AD000864
    4. NM_032721.3NP_116110.2  NF-kappa-B inhibitor delta isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes isoform 3.
      Source sequence(s)
      AD000864, AF385433
      Consensus CDS
      CCDS92601.1
      UniProtKB/TrEMBL
      K7EKM2
      Related
      ENSP00000475712.2, ENST00000606253.5
      Conserved Domains (4) summary
      cd00204
      Location:231379
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:304355
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:334430
      Ank_2; Ankyrin repeats (3 copies)
      cl26464
      Location:70178
      Atrophin-1; Atrophin-1 family
    5. NM_139239.5NP_640332.2  NF-kappa-B inhibitor delta isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1 and uses a non-AUG (CUG) translation initiation codon.
      Source sequence(s)
      AD000864
      UniProtKB/TrEMBL
      A0A286YF31
      Related
      ENSP00000493265.2, ENST00000641389.3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      35887952..35902303 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      38433711..38448068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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