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    ZNF281 zinc finger protein 281 [ Homo sapiens (human) ]

    Gene ID: 23528, updated on 3-Nov-2024

    Summary

    Official Symbol
    ZNF281provided by HGNC
    Official Full Name
    zinc finger protein 281provided by HGNC
    Primary source
    HGNC:HGNC:13075
    See related
    Ensembl:ENSG00000162702 MIM:618703; AllianceGenome:HGNC:13075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GZP1; ZBP99; ZBP-99; ZNP-99
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; and positive regulation of DNA-templated transcription. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 10.1), appendix (RPKM 5.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF281 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (200404951..200410036, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (199661900..199740523, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (200374079..200379164, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1669 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:200271617-200271834 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:200321702-200322202 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:200322203-200322703 Neighboring gene long intergenic non-protein coding RNA 862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200324513-200325012 Neighboring gene Sharpr-MPRA regulatory regions 7059 and 708 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:200341274-200341804 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:200343201-200344400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2297 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200378413-200378990 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:200378991-200379568 Neighboring gene NANOG hESC enhancer GRCh37_chr1:200379569-200380146 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:200380418-200381024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200385505-200386006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200386007-200386506 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:200388206-200388706 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:200388707-200389207 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200396646-200397146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200397147-200397647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2300 Neighboring gene uncharacterized LOC124900414 Neighboring gene uncharacterized LOC124904480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1671 Neighboring gene uncharacterized LOC107985459

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ12859, FLJ14378

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in nucleoplasm  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    zinc finger protein 281
    Names
    GC-box-binding zinc finger protein 1
    ZNP-99 transcription factor
    transcription factor ZBP-99
    zinc finger DNA-binding protein 99

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281293.2NP_001268222.1  zinc finger protein 281 isoform 1

      See identical proteins and their annotated locations for NP_001268222.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AC104461, AJ132592, BP216938
      Consensus CDS
      CCDS1402.1
      UniProtKB/Swiss-Prot
      A6NF48, B3KMX2, Q5RKW5, Q9NY92, Q9Y2X9
      Related
      ENSP00000356322.1, ENST00000367353.2
      Conserved Domains (2) summary
      sd00017
      Location:263283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:331356
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001281294.2NP_001268223.1  zinc finger protein 281 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is missing an internal segment compared to isoform 1.
      Source sequence(s)
      AC104461, AK022921, AK094701, BC051905, BG611294, DB150929
      Consensus CDS
      CCDS60384.1
      UniProtKB/Swiss-Prot
      Q9Y2X9
      UniProtKB/TrEMBL
      B3KMX4
      Related
      ENSP00000356321.3, ENST00000367352.3
      Conserved Domains (3) summary
      sd00017
      Location:227247
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:225247
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:295320
      zf-H2C2_2; Zinc-finger double domain
    3. NM_012482.5NP_036614.1  zinc finger protein 281 isoform 1

      See identical proteins and their annotated locations for NP_036614.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AC104461, BC060820
      Consensus CDS
      CCDS1402.1
      UniProtKB/Swiss-Prot
      A6NF48, B3KMX2, Q5RKW5, Q9NY92, Q9Y2X9
      Related
      ENSP00000294740.2, ENST00000294740.3
      Conserved Domains (2) summary
      sd00017
      Location:263283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:331356
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      200404951..200410036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      199661900..199740523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335706.1XP_054191681.1  zinc finger protein 281 isoform X1

      UniProtKB/Swiss-Prot
      A6NF48, B3KMX2, Q5RKW5, Q9NY92, Q9Y2X9
    2. XM_054335707.1XP_054191682.1  zinc finger protein 281 isoform X1

      UniProtKB/Swiss-Prot
      A6NF48, B3KMX2, Q5RKW5, Q9NY92, Q9Y2X9
    3. XM_054335708.1XP_054191683.1  zinc finger protein 281 isoform X1

      UniProtKB/Swiss-Prot
      A6NF48, B3KMX2, Q5RKW5, Q9NY92, Q9Y2X9
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