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    xpo-1 Exportin-1 C-terminal domain-containing protein;Importin N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179160, updated on 2-Nov-2024

    Summary

    Official Symbol
    xpo-1
    Official Full Name
    Exportin-1 C-terminal domain-containing protein;Importin N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00002078
    Locus tag
    CELE_ZK742.1
    See related
    AllianceGenome:WB:WBGene00002078
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable nuclear export signal receptor activity. Predicted to be involved in ribosomal large subunit export from nucleus and ribosomal small subunit export from nucleus. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer; gastric adenocarcinoma; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human XPO1 (exportin 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See xpo-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (7805064..7814584)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene UV-stimulated scaffold protein A homolog Neighboring gene ncRNA Neighboring gene NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein Neighboring gene NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Fatty acid-binding protein homolog 4 Neighboring gene Papilin Neighboring gene EGF-like domain-containing protein Neighboring gene Transthyretin-like protein 33

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables nuclear export signal receptor activity  
    enables nuclear export signal receptor activity  
    enables small GTPase binding  
    Process Evidence Code Pubs
    involved_in intracellular protein transport  
    involved_in protein export from nucleus  
    involved_in protein transport  
    involved_in ribosomal large subunit export from nucleus  
    involved_in ribosomal small subunit export from nucleus  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    Exportin-1 C-terminal domain-containing protein;Importin N-terminal domain-containing protein
    NP_001367571.1
    • Confirmed by transcript evidence
    NP_741567.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      7805064..7814584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171484.8NP_741567.1  Importin N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741567.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23089
      Conserved Domains (1) summary
      COG5101
      Location:221062
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
    2. NM_001380696.1NP_001367571.1  Exportin-1 C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MPS6
      Conserved Domains (1) summary
      cl07396
      Location:139
      CRM1_C; CRM1 C terminal
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