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| Status |
Public on Jul 01, 2021 |
| Title |
Microarray expression profiling of circular RNAs in human esophageal carcinoma |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Using the highly sensitive microarray, 102 circRNAs and 67 circRNAs significantly upregulated and downregulated, respectively, were distinguished by Arraystar platform, in esophageal carcinoma (EC) tumors relative to adjacent normal tissue. Hsa_circRNA_401955 showed the most connection, thus regarded as the hub gene. Hsa_circRNA_100375 and its four connected MREs axis played a key role in the cancer related pathway of EC. CircRNA dysregulation may be involved in the tumorigenesis of EC and certain circRNAs may become new biomarker and therapeutic target for EC.
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| Overall design |
To characterize different expressed of circRNA in esophageal carcinoma, ten samples including five tumor tissues and five matched normal adjacent tissues from patients were detected by microarray.
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| Contributor(s) |
Chen XH, Cai SN |
| Citation(s) |
35557573 |
| |
| Submission date |
Aug 25, 2017 |
| Last update date |
May 25, 2022 |
| Contact name |
Xiaohua Chen |
| E-mail(s) |
cxh0663@126.com
|
| Phone |
00-86-020-34859211
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| Organization name |
Panyu Central Hospital
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| Street address |
Fuyudong Road 8，Qiaonan street，Panyu
|
| City |
Guangzhou |
| State/province |
Guangdong |
| ZIP/Postal code |
511400 |
| Country |
China |
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| Platforms (1) |
| GPL21825 |
074301 Arraystar Human CircRNA microarray V2 |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA400190 |
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