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| Status |
Public on Dec 31, 2022 |
| Title |
Expression array of DNMT1 inhibitor treated AML cell lines |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Genome wide demethylation by DNMT1 inhibitor GSK3484862 results in up-regulation of epigenetically-silenced genes. Differential expression was perfomed for each cell line following DNMT1 inhibitor or vehicle treatment. Differentially epressed gene lists were submitted to gene set enrichment analysis (GSEA) to identify consistently changed pathways.
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| Overall design |
Seven AML cell lines were treated for 96 hours in biological duplicate with 0.1% DMSO or 1 µM GSK3484862 before isolating RNA, labeling, and hybridizing to Affymetrix GeneChip® Human Genome U1331 Plus 2.0 arrays.
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| Contributor(s) |
Pappalardi MB, McCabe MT, Kellner WA, Keenan K |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jul 23, 2019 |
| Last update date |
Jan 02, 2023 |
| Contact name |
Shawn W Foley |
| E-mail(s) |
shawn.w.foley@gsk.com
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| Organization name |
GlaxoSmithKline
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| Department |
Oncology
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| Street address |
1250 S. Collegeville Rd
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| City |
Collegeville |
| State/province |
PA |
| ZIP/Postal code |
19426 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (28)
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| GSM3964061 |
M4-20, GDM1.1uM.GSK862.d4.n2.n2 |
| GSM3964062 |
M4-05, MOLM13.0uM.DMSO.d4.n1.n1 |
| GSM3964063 |
M4-21, MOLM13.0uM.DMSO.d4.n2.n2 |
| GSM3964064 |
M4-06, MOLM13.1uM.GSK862.d4.n1.n1 |
| GSM3964065 |
M4-22, MOLM13.1uM.GSK862.d4.n2.n2 |
| GSM3964066 |
M4-01, SKM1.0uM.DMSO.d4.n1.n1 |
| GSM3964067 |
M4-17, SKM1.0uM.DMSO.d4.n2.n2 |
| GSM3964068 |
M4-02, SKM1.1uM.GSK862.d4.n1.n1 |
| GSM3964069 |
M4-18, SKM1.1uM.GSK862.d4.n2.n2 |
| GSM3964070 |
M4-07, THP1.0uM.DMSO.d4.n1.n1 |
| GSM3964071 |
M4-23, THP1.0uM.DMSO.d4.n2.n2 |
| GSM3964072 |
M4-08, THP1.1uM.GSK862.d4.n1.n1 |
| GSM3964073 |
M4-24, THP1.1uM.GSK862.d4.n2.n2 |
| GSM3964074 |
M4-15, SKNO1.0uM.DMSO.d4.n1.n1 |
| GSM3964075 |
M4-31, SKNO1.0uM.DMSO.d4.n2.n2 |
| GSM3964076 |
M4-16, SKNO1.1uM.GSK862.d4.n1.n1 |
| GSM3964077 |
M4-32, SKNO1.1uM.GSK862.d4.n2.n2 |
| GSM3964078 |
M4-11, NOMO1.0uM.DMSO.d4.n1.n1 |
| GSM3964079 |
M4-27, NOMO1.0uM.DMSO.d4.n2.n2 |
| GSM3964080 |
M4-12, NOMO1.1uM.GSK862.d4.n1.n1 |
| GSM3964081 |
M4-28, NOMO1.1uM.GSK862.d4.n2.n2 |
| GSM3964082 |
M4-09, SHI1.0uM.DMSO.d4.n1.n1 |
| GSM3964083 |
M4-25, SHI1.0uM.DMSO.d4.n2.n2 |
| GSM3964084 |
M4-10, SHI1.1uM.GSK862.d4.n1.n1 |
| GSM3964085 |
M4-26, SHI1.1uM.GSK862.d4.n2.n2 |
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| Relations |
| BioProject |
PRJNA556213 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE134716_RAW.tar |
144.2 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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