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| Status |
Public on May 20, 2009 |
| Title |
Characterisation of gene expression changes in T cells from patients presenting with AML compared with healthy T cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Work previously published by our group has demonstrated that T cells from patients with chronic lymphocytic leukaemia (CLL) show differentially regulated genes compared with healthy T cells. This study was initiated to examine if these gene expression changes were unique to CLL T cells or common to an alternative leukaemia, acute myeloid leukaemia (AML).
Keywords: Comparison of immune cells in health and disease
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| Overall design |
The study was composed of four groups of samples: AML CD4 (n=10), AML CD8 (n=10), Healthy CD4 (n=10), Healthy CD8 (n=11). AML samples were chosen to represent the range of FAB types, prognostic groups and patient outcomes. Healthy T cells were obtained from volunteers. The purity of isolated T cell fractions was greater than 70% in all cases.
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| Contributor(s) |
Le Dieu R, Mitter R |
| Citation(s) |
19710498 |
| |
| Submission date |
Feb 20, 2009 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Rifca Le Dieu |
| E-mail(s) |
rledieu@gmail.com
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| Organization name |
Queen Mary University of London
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| Department |
Institute of Cancer
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| Lab |
Centre for Medical Oncology
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| Street address |
3rd Floor, John Vane Science Building, Charterhouse Square
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| City |
London |
| ZIP/Postal code |
EC1M 6BQ |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (41)
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| Relations |
| BioProject |
PRJNA111913 |
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