|
| Status |
Public on Jan 27, 2021 |
| Title |
Understanding BRCA1 function in INK4-RB deficient tumors |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Most BRCA1-deficient BLBCs carry a dysfunctional INK4-RB pathway.
Thus, we have created genetically engineered mice with Brca1 loss and deletion of p16INK4A, or separately p18INK4C, to model the deficient INK4-RB signaling in human BLBC. By using these mutant mice and human BRCA1 deficient and proficient breast cancer tissues and cells, we tested if there exists a druggable target in BRCA1 deficient breast cancers.
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| |
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| Overall design |
Gene expression microarray analysis of mouse mammary tumors.
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| |
|
| Contributor(s) |
Perou CM, Hollern D |
| Citation(s) |
33478572, 35236825 |
| |
| Submission date |
Jul 27, 2020 |
| Last update date |
Mar 30, 2022 |
| Contact name |
Charles M. Perou |
| E-mail(s) |
cperou@med.unc.edu
|
| Organization name |
University of North Carolina at Chapel Hill
|
| Department |
Professor of Genetics, and Pathology & Laboratory Medicine; Lineberger Comprehensive Cancer Center
|
| Street address |
12-044 Lineberger Comprehensive Cancer Center CB# 7295
|
| City |
Chapel Hill |
| State/province |
NC |
| ZIP/Postal code |
27599-7264 |
| Country |
USA |
| |
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| Platforms (2) |
| GPL2881 |
Agilent-013326 Mouse Oligo Microarray (V2) G4121B (Feature Number version) |
| GPL10732 |
Mouse-Agilent-22K-D20030711 |
|
| Samples (21)
|
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| Relations |
| BioProject |
PRJNA655906 |
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